Names & Taxonomy

Uniprot ID:
O14880
Entry Name:
MGST3_HUMAN
Status:
reviewed
Protein Names:
Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) (Microsomal GST-III)
Gene Names:
MGST3
Gene Names Primary:
MGST3
Organism:
Homo sapiens (Human)

Structure

Length:
152
Sequence:
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSIALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Also functions as a glutathione peroxidase.
Catalytic Activity:
RX + glutathione = HX + R-S-glutathione.
Cross Reference Drug Bank:
DB00143
Gene Ontology Go:
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
membrane
glutathione peroxidase activity
glutathione transferase activity
peroxidase activity
cellular oxidant detoxification
glutathione derivative biosynthetic process
lipid metabolic process
response to organonitrogen compound
signal transduction
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular oxidant detoxification
glutathione derivative biosynthetic process
lipid metabolic process
response to organonitrogen compound
signal transduction
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
glutathione peroxidase activity
glutathione transferase activity
peroxidase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
membrane
Keywords:
Complete proteome
Endoplasmic reticulum
Lipoprotein
Membrane
Microsome
Palmitate
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix
Interacts With:
P24863

Publication

PubMed ID:
9278457 14702039 16710414 15489334 21269460 21044946 24275569 25944712