Names & Taxonomy
- Uniprot ID:
- O14788
- Entry Name:
- TNF11_HUMAN
- Status:
- reviewed
- Protein Names:
- Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
- Gene Names:
- TNFSF11 OPGL RANKL TRANCE
- Gene Names Primary:
- TNFSF11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 317
- Sequence:
- MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type II membrane protein.; Isoform 3: Cell membrane; Single-pass type II membrane protein.; Isoform 2: Cytoplasm
Function
- Function:
- Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).
- Cross Reference Drug Bank:
- DB06643 DB00480
- Gene Ontology Go:
- cytoplasm
extracellular region
extracellular space
integral component of plasma membrane
plasma membrane
cytokine activity
tumor necrosis factor receptor binding
tumor necrosis factor receptor superfamily binding
activation of JUN kinase activity
bone resorption
calcium ion homeostasis
cytokine-mediated signaling pathway
ERK1 and ERK2 cascade
immune response
mammary gland alveolus development
mammary gland epithelial cell proliferation
monocyte chemotaxis
organ morphogenesis
ossification
osteoclast differentiation
osteoclast proliferation
paracrine signaling
positive regulation of bone resorption
positive regulation of corticotropin-releasing hormone secretion
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
positive regulation of fever generation by positive regulation of prostaglandin secretion
positive regulation of homotypic cell-cell adhesion
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of intracellular signal transduction
positive regulation of MAP kinase activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of osteoclast development
positive regulation of osteoclast differentiation
positive regulation of protein kinase B signaling
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of T cell activation
positive regulation of transcription from RNA polymerase II promoter
protein homooligomerization
TNFSF11-mediated signaling pathway
tumor necrosis factor-mediated signaling pathway - Gene Ontology Biological Process:
- activation of JUN kinase activity
bone resorption
calcium ion homeostasis
cytokine-mediated signaling pathway
ERK1 and ERK2 cascade
immune response
mammary gland alveolus development
mammary gland epithelial cell proliferation
monocyte chemotaxis
organ morphogenesis
ossification
osteoclast differentiation
osteoclast proliferation
paracrine signaling
positive regulation of bone resorption
positive regulation of corticotropin-releasing hormone secretion
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
positive regulation of fever generation by positive regulation of prostaglandin secretion
positive regulation of homotypic cell-cell adhesion
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of intracellular signal transduction
positive regulation of MAP kinase activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of osteoclast development
positive regulation of osteoclast differentiation
positive regulation of protein kinase B signaling
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of T cell activation
positive regulation of transcription from RNA polymerase II promoter
protein homooligomerization
TNFSF11-mediated signaling pathway
tumor necrosis factor-mediated signaling pathway - Gene Ontology Molecular Function:
- cytokine activity
tumor necrosis factor receptor binding
tumor necrosis factor receptor superfamily binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular region
extracellular space
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Cytokine
Cytoplasm
Developmental protein
Differentiation
Disease mutation
Glycoprotein
Membrane
Osteopetrosis
Receptor
Reference proteome
Secreted
Signal-anchor
Transmembrane
Transmembrane helix