Names & Taxonomy

Uniprot ID:
O14786
Entry Name:
NRP1_HUMAN
Status:
reviewed
Protein Names:
Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
Gene Names:
NRP1 NRP VEGF165R
Gene Names Primary:
NRP1
Organism:
Homo sapiens (Human)

Structure

Length:
923
Sequence:
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.

Function

Function:
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.; The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Cross Reference Drug Bank:
DB00039 DB04895
Gene Ontology Go:
axon
cell surface
cytoplasmic vesicle
cytosol
early endosome
extracellular space
focal adhesion
growth cone
integral component of membrane
neurofilament
neuronal cell body
plasma membrane
receptor complex
semaphorin receptor complex
sorting endosome
coreceptor activity
cytokine binding
growth factor binding
heparin binding
metal ion binding
semaphorin receptor activity
vascular endothelial growth factor binding
vascular endothelial growth factor-activated receptor activity
angiogenesis
angiogenesis involved in coronary vascular morphogenesis
artery morphogenesis
axon extension involved in axon guidance
axon guidance
axonal fasciculation
axonogenesis involved in innervation
branchiomotor neuron axon guidance
cell migration involved in sprouting angiogenesis
cell-cell signaling
cellular response to hepatocyte growth factor stimulus
cellular response to vascular endothelial growth factor stimulus
commissural neuron axon guidance
coronary artery morphogenesis
dendrite development
dichotomous subdivision of terminal units involved in salivary gland branching
dorsal root ganglion morphogenesis
endothelial cell chemotaxis
endothelial tip cell fate specification
facial nerve structural organization
facioacoustic ganglion development
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
hepatocyte growth factor receptor signaling pathway
negative regulation of axon extension involved in axon guidance
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of neuron apoptotic process
nerve development
neural crest cell migration involved in autonomic nervous system development
neuron migration
organ morphogenesis
otic placode formation
patterning of blood vessels
platelet-derived growth factor receptor signaling pathway
positive chemotaxis
positive regulation of axon extension involved in axon guidance
positive regulation of cytokine activity
positive regulation of endothelial cell migration
positive regulation of endothelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of retinal ganglion cell axon guidance
positive regulation of smooth muscle cell migration
protein localization to early endosome
regulation of retinal ganglion cell axon guidance
regulation of vesicle-mediated transport
renal artery morphogenesis
response to wounding
retina vasculature morphogenesis in camera-type eye
retinal ganglion cell axon guidance
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin-plexin signaling pathway involved in neuron projection guidance
sensory neuron axon guidance
signal transduction
sprouting angiogenesis
sympathetic ganglion development
sympathetic neuron projection extension
sympathetic neuron projection guidance
toxin transport
trigeminal ganglion development
trigeminal nerve structural organization
vascular endothelial growth factor receptor signaling pathway
VEGF-activated neuropilin signaling pathway
VEGF-activated neuropilin signaling pathway involved in axon guidance
ventral trunk neural crest cell migration
vestibulocochlear nerve structural organization
Gene Ontology Biological Process:
angiogenesis
angiogenesis involved in coronary vascular morphogenesis
artery morphogenesis
axonal fasciculation
axon extension involved in axon guidance
axon guidance
axonogenesis involved in innervation
branchiomotor neuron axon guidance
cell-cell signaling
cell migration involved in sprouting angiogenesis
cellular response to hepatocyte growth factor stimulus
cellular response to vascular endothelial growth factor stimulus
commissural neuron axon guidance
coronary artery morphogenesis
dendrite development
dichotomous subdivision of terminal units involved in salivary gland branching
dorsal root ganglion morphogenesis
endothelial cell chemotaxis
endothelial tip cell fate specification
facial nerve structural organization
facioacoustic ganglion development
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
hepatocyte growth factor receptor signaling pathway
negative regulation of axon extension involved in axon guidance
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of neuron apoptotic process
nerve development
neural crest cell migration involved in autonomic nervous system development
neuron migration
organ morphogenesis
otic placode formation
patterning of blood vessels
platelet-derived growth factor receptor signaling pathway
positive chemotaxis
positive regulation of axon extension involved in axon guidance
positive regulation of cytokine activity
positive regulation of endothelial cell migration
positive regulation of endothelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of retinal ganglion cell axon guidance
positive regulation of smooth muscle cell migration
protein localization to early endosome
regulation of retinal ganglion cell axon guidance
regulation of vesicle-mediated transport
renal artery morphogenesis
response to wounding
retinal ganglion cell axon guidance
retina vasculature morphogenesis in camera-type eye
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin-plexin signaling pathway involved in neuron projection guidance
sensory neuron axon guidance
signal transduction
sprouting angiogenesis
sympathetic ganglion development
sympathetic neuron projection extension
sympathetic neuron projection guidance
toxin transport
trigeminal ganglion development
trigeminal nerve structural organization
vascular endothelial growth factor receptor signaling pathway
VEGF-activated neuropilin signaling pathway
VEGF-activated neuropilin signaling pathway involved in axon guidance
ventral trunk neural crest cell migration
vestibulocochlear nerve structural organization
Gene Ontology Molecular Function:
coreceptor activity
cytokine binding
growth factor binding
heparin binding
metal ion binding
semaphorin receptor activity
vascular endothelial growth factor-activated receptor activity
vascular endothelial growth factor binding
Gene Ontology Cellular Component:
axon
cell surface
cytoplasmic vesicle
cytosol
early endosome
extracellular space
focal adhesion
growth cone
integral component of membrane
neurofilament
neuronal cell body
plasma membrane
receptor complex
semaphorin receptor complex
sorting endosome
Keywords:
3D-structure
Alternative splicing
Angiogenesis
Calcium
Cell membrane
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Glycoprotein
Heparan sulfate
Heparin-binding
Membrane
Metal-binding
Neurogenesis
Phosphoprotein
Polymorphism
Proteoglycan
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix
Interacts With:
P21333; P35968; P15692; P15692-4

Publication

PubMed ID:
9288753 9529250 10688880 17974005 15164054 15489334 10520995 10748121 16335952 16763549 19159218 24275569 12517344 17989695