Names & Taxonomy

Uniprot ID:
O14746
Entry Name:
TERT_HUMAN
Status:
reviewed
Protein Names:
Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2)
Gene Names:
TERT EST2 TCS1 TRT
Gene Names Primary:
TERT
Organism:
Homo sapiens (Human)

Structure

Length:
1132
Sequence:
MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus, nucleolus

Function

Function:
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
Catalytic Activity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Cross Reference Drug Bank:
DB00495
Gene Ontology Go:
chromosome, telomeric region
mitochondrial nucleoid
nuclear chromosome, telomeric region
nuclear telomere cap complex
nucleolus
nucleoplasm
nucleus
PML body
RNA-directed RNA polymerase complex
telomerase catalytic core complex
telomerase holoenzyme complex
TERT-RMRP complex
DNA binding
metal ion binding
nucleotidyltransferase activity
protein homodimerization activity
RNA binding
RNA-directed DNA polymerase activity
telomerase activity
telomerase RNA binding
telomerase RNA reverse transcriptase activity
telomeric DNA binding
transcription coactivator binding
tRNA binding
cellular response to hypoxia
DNA biosynthetic process
DNA strand elongation
establishment of protein localization to telomere
mitochondrion organization
negative regulation of cellular senescence
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of gene expression
negative regulation of production of siRNA involved in RNA interference
positive regulation of hair cycle
positive regulation of nitric-oxide synthase activity
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of protein binding
positive regulation of protein localization to nucleolus
positive regulation of stem cell proliferation
positive regulation of Wnt signaling pathway
production of siRNA involved in RNA interference
regulation of protein stability
replicative senescence
RNA biosynthetic process
RNA-dependent DNA replication
telomere maintenance
telomere maintenance via telomerase
transcription, RNA-templated
Gene Ontology Biological Process:
cellular response to hypoxia
DNA biosynthetic process
DNA strand elongation
establishment of protein localization to telomere
mitochondrion organization
negative regulation of cellular senescence
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of gene expression
negative regulation of production of siRNA involved in RNA interference
positive regulation of hair cycle
positive regulation of nitric-oxide synthase activity
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of protein binding
positive regulation of protein localization to nucleolus
positive regulation of stem cell proliferation
positive regulation of Wnt signaling pathway
production of siRNA involved in RNA interference
regulation of protein stability
replicative senescence
RNA biosynthetic process
RNA-dependent DNA replication
telomere maintenance
telomere maintenance via telomerase
transcription, RNA-templated
Gene Ontology Molecular Function:
DNA binding
metal ion binding
nucleotidyltransferase activity
protein homodimerization activity
RNA binding
RNA-directed DNA polymerase activity
telomerase activity
telomerase RNA binding
telomerase RNA reverse transcriptase activity
telomeric DNA binding
transcription coactivator binding
tRNA binding
Gene Ontology Cellular Component:
chromosome, telomeric region
mitochondrial nucleoid
nuclear chromosome, telomeric region
nuclear telomere cap complex
nucleolus
nucleoplasm
nucleus
PML body
RNA-directed RNA polymerase complex
telomerase catalytic core complex
telomerase holoenzyme complex
TERT-RMRP complex
Keywords:
3D-structure
Alternative splicing
Chromosome
Complete proteome
Cytoplasm
DNA-binding
Disease mutation
Dyskeratosis congenita
Magnesium
Metal-binding
Nucleotidyltransferase
Nucleus
Phosphoprotein
Polymorphism
RNA-directed DNA polymerase
Reference proteome
Ribonucleoprotein
Telomere
Transferase
Ubl conjugation
Interacts With:
Q9BVP2; P29590-5; Q9Y265; Q92900

Publication

PubMed ID:
9288757 9252327 10333526 12869302 14654914 15372022 8676067 9389643 9443919 11029039 11274138 12808100 15044100 14963003 15138842 15371412 15082768 15805468 15857955 17026956 17548608 18082603 17296728 17264120 18829466 19188162 19567472 19571879 19777057 19179534 22226966 22366458 23362280 23612978 23348503 16323248 15885610 15814878 16247010 16890917 16332973 16627250 16990594 17785587 17392301 17460043 18042801 19760749 19147845 21436073 21483807 22512499