Names & Taxonomy
- Uniprot ID:
- O14717
- Entry Name:
- TRDMT_HUMAN
- Status:
- reviewed
- Protein Names:
- tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet)
- Gene Names:
- TRDMT1 DNMT2
- Gene Names Primary:
- TRDMT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 391
- Sequence:
- MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
- Catalytic Activity:
- S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(38) in tRNA.
- Active Site:
- ACT_SITE 79 79
- Cross Reference Drug Bank:
- DB00738
- Gene Ontology Go:
- cytoplasm
nucleoplasm
DNA (cytosine-5-)-methyltransferase activity
RNA binding
tRNA methyltransferase activity
C-5 methylation of cytosine
gene expression
response to amphetamine
tRNA methylation
tRNA modification
tRNA processing - Gene Ontology Biological Process:
- C-5 methylation of cytosine
gene expression
response to amphetamine
tRNA methylation
tRNA modification
tRNA processing - Gene Ontology Molecular Function:
- DNA (cytosine-5-)-methyltransferase activity
RNA binding
tRNA methyltransferase activity - Gene Ontology Cellular Component:
- cytoplasm
nucleoplasm - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Methyltransferase
Nucleus
Polymorphism
RNA-binding
Reference proteome
S-adenosyl-L-methionine
Transferase
tRNA processing