Names & Taxonomy
- Uniprot ID:
- O14522
- Entry Name:
- PTPRT_HUMAN
- Status:
- reviewed
- Protein Names:
- Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)
- Gene Names:
- PTPRT KIAA0283
- Gene Names Primary:
- PTPRT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1441
- Sequence:
- MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- May be involved in both signal transduction and cellular adhesion in the CNS.
- Catalytic Activity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- Active Site:
- ACT_SITE 1084 1084 Phosphocysteine intermediate.
- Gene Ontology Go:
- cell surface
integral component of membrane
plasma membrane
alpha-catenin binding
beta-catenin binding
cadherin binding
delta-catenin binding
gamma-catenin binding
protein tyrosine phosphatase activity
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
peptidyl-tyrosine dephosphorylation
protein dephosphorylation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Biological Process:
- cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
peptidyl-tyrosine dephosphorylation
protein dephosphorylation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Molecular Function:
- alpha-catenin binding
beta-catenin binding
cadherin binding
delta-catenin binding
gamma-catenin binding
protein tyrosine phosphatase activity - Gene Ontology Cellular Component:
- cell surface
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Protein phosphatase
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P62993; Q99K10; Q69ZK9; Q9CS84; Q6P9K9; Q16849