Names & Taxonomy
- Uniprot ID:
- O00519
- Entry Name:
- FAAH1_HUMAN
- Status:
- reviewed
- Protein Names:
- Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Oleamide hydrolase 1)
- Gene Names:
- FAAH FAAH1
- Gene Names Primary:
- FAAH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 579
- Sequence:
- MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endomembrane system
- Intramembrane:
- INTRAMEM 404 433
Function
- Function:
- Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
- Catalytic Activity:
- Anandamide + H(2)O = arachidonic acid + ethanolamine.; Oleamide + H(2)O = oleic acid + NH(3).
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by O-aryl carbamates and alpha-keto heterocytes.
- Active Site:
- ACT_SITE 142 142 Charge relay system.
- Cross Reference Drug Bank:
- DB00818 DB00599
- Gene Ontology Go:
- cytoskeleton
endoplasmic reticulum membrane
integral component of membrane
organelle membrane
acylglycerol lipase activity
carbon-nitrogen ligase activity, with glutamine as amido-N-donor
fatty acid amide hydrolase activity
arachidonic acid metabolic process
fatty acid catabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
fatty acid catabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- acylglycerol lipase activity
carbon-nitrogen ligase activity, with glutamine as amido-N-donor
fatty acid amide hydrolase activity - Gene Ontology Cellular Component:
- cytoskeleton
endoplasmic reticulum membrane
integral component of membrane
organelle membrane - Keywords:
- Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Hydrolase
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix - Interacts With:
- Q7Z3S9