Names & Taxonomy

Uniprot ID:
O00469
Entry Name:
PLOD2_HUMAN
Status:
reviewed
Protein Names:
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2)
Gene Names:
PLOD2
Gene Names Primary:
PLOD2
Organism:
Homo sapiens (Human)

Structure

Length:
737
Sequence:
MGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQDNGCTLCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLTLDYPKEALKLFIHNKEVYHEKDIKVFFDKAKHEIKTIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGVWNVPYMANVYLIKGKTLRSEMNERNYFVRDKLDPDMALCRNAREMGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQVDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.

Function

Function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Catalytic Activity:
L-lysine- + 2-oxoglutarate + O(2) = (2S,5R)-5-hydroxy-L-lysine- + succinate + CO(2).
Cofactor:
COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Active Site:
ACT_SITE 728 728
Cross Reference Drug Bank:
DB00126
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
rough endoplasmic reticulum membrane
iron ion binding
L-ascorbic acid binding
procollagen-lysine 5-dioxygenase activity
cellular protein modification process
cellular response to hormone stimulus
extracellular matrix organization
mitophagy in response to mitochondrial depolarization
response to hypoxia
Gene Ontology Biological Process:
cellular protein modification process
cellular response to hormone stimulus
extracellular matrix organization
mitophagy in response to mitochondrial depolarization
response to hypoxia
Gene Ontology Molecular Function:
iron ion binding
L-ascorbic acid binding
procollagen-lysine 5-dioxygenase activity
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
rough endoplasmic reticulum membrane
Keywords:
Alternative splicing
Complete proteome
Dioxygenase
Disease mutation
Endoplasmic reticulum
Glycoprotein
Iron
Membrane
Metal-binding
Osteogenesis imperfecta
Oxidoreductase
Phosphoprotein
Reference proteome
Signal
Vitamin C

Publication

PubMed ID:
9054364 14702039 16641997 10372558 15489334 18088087 19159218 21269460 12881513 15523624 22689593