Names & Taxonomy
- Uniprot ID:
- O00408
- Entry Name:
- PDE2A_HUMAN
- Status:
- reviewed
- Protein Names:
- cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)
- Gene Names:
- PDE2A
- Gene Names Primary:
- PDE2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 941
- Sequence:
- MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform PDE2A3: Cell membrane
Function
- Function:
- Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.; Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.
- Catalytic Activity:
- Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Active Site:
- ACT_SITE 656 656 Proton donor.
- Cross Reference Drug Bank:
- DB00201 DB08811
- Gene Ontology Go:
- cytoplasm
cytosol
endoplasmic reticulum
Golgi apparatus
membrane raft
mitochondrial matrix
nucleus
perinuclear region of cytoplasm
plasma membrane
presynaptic membrane
calcium channel activity
cAMP binding
cGMP binding
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cyclic-nucleotide phosphodiesterase activity
drug binding
metal ion binding
protein homodimerization activity
TPR domain binding
blood coagulation
calcium ion transmembrane transport
cAMP catabolic process
cAMP-mediated signaling
cellular response to cGMP
cellular response to drug
cellular response to granulocyte macrophage colony-stimulating factor stimulus
cellular response to macrophage colony-stimulating factor stimulus
cellular response to mechanical stimulus
cellular response to transforming growth factor beta stimulus
cGMP catabolic process
cGMP-mediated signaling
establishment of endothelial barrier
metabolic process
monocyte differentiation
negative regulation of cAMP biosynthetic process
negative regulation of protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of vascular permeability
positive regulation of inflammatory response
positive regulation of vascular permeability
protein targeting to mitochondrion - Gene Ontology Biological Process:
- blood coagulation
calcium ion transmembrane transport
cAMP catabolic process
cAMP-mediated signaling
cellular response to cGMP
cellular response to drug
cellular response to granulocyte macrophage colony-stimulating factor stimulus
cellular response to macrophage colony-stimulating factor stimulus
cellular response to mechanical stimulus
cellular response to transforming growth factor beta stimulus
cGMP catabolic process
cGMP-mediated signaling
establishment of endothelial barrier
metabolic process
monocyte differentiation
negative regulation of cAMP biosynthetic process
negative regulation of protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of vascular permeability
positive regulation of inflammatory response
positive regulation of vascular permeability
protein targeting to mitochondrion - Gene Ontology Molecular Function:
- calcium channel activity
cAMP binding
cGMP binding
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cyclic-nucleotide phosphodiesterase activity
drug binding
metal ion binding
protein homodimerization activity
TPR domain binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
endoplasmic reticulum
Golgi apparatus
membrane raft
mitochondrial matrix
nucleus
perinuclear region of cytoplasm
plasma membrane
presynaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Hydrolase
Lipoprotein
Membrane
Metal-binding
Mitochondrion
Myristate
Nucleotide-binding
Palmitate
Polymorphism
Reference proteome
Repeat
cAMP
cGMP
cGMP-binding - Interacts With:
- O00170