Names & Taxonomy
- Uniprot ID:
- O00341
- Entry Name:
- EAA5_HUMAN
- Status:
- reviewed
- Protein Names:
- Excitatory amino acid transporter 5 (Retinal glutamate transporter) (Solute carrier family 1 member 7)
- Gene Names:
- SLC1A7 EAAT5
- Gene Names Primary:
- SLC1A7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 560
- Sequence:
- MVPHAILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAPPRRILIYGVQEENGSHVQNFALDLTPPPEVVYKSEPGTSDGMNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHICRKDFARDTGTEKLLPCETKPVSLQEIVAAQQNGCVKSVAEASELTLGPTCPHHVPVQVEQDEELPAASLNHCTIQISELETNV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.
- Gene Ontology Go:
- integral component of membrane
plasma membrane
presynapse
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity
dicarboxylic acid transport
glutamate secretion
ion transport
L-glutamate transmembrane transport
neurotransmitter secretion
synaptic transmission
transmembrane transport - Gene Ontology Biological Process:
- dicarboxylic acid transport
glutamate secretion
ion transport
L-glutamate transmembrane transport
neurotransmitter secretion
synaptic transmission
transmembrane transport - Gene Ontology Molecular Function:
- L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane
presynapse - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport