Names & Taxonomy

Uniprot ID:
O00305
Entry Name:
CACB4_HUMAN
Status:
reviewed
Protein Names:
Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4)
Gene Names:
CACNB4 CACNLB4
Gene Names Primary:
CACNB4
Organism:
Homo sapiens (Human)

Structure

Length:
520
Sequence:
MSSSSYAKNGTADGPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL
Proteomes:
UP000005640

Function

Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Cross Reference Drug Bank:
DB04855 DB00393 DB00421 DB00661
Gene Ontology Go:
cytoplasmic side of plasma membrane
cytosol
plasma membrane
synapse
voltage-gated calcium channel complex
voltage-gated calcium channel activity
adult walking behavior
axon guidance
calcium ion transmembrane transport
cAMP metabolic process
cardiac conduction
cellular calcium ion homeostasis
detection of light stimulus involved in visual perception
gamma-aminobutyric acid secretion
gamma-aminobutyric acid signaling pathway
membrane depolarization
muscle fiber development
neuromuscular junction development
neuronal action potential propagation
Peyer's patch development
regulation of voltage-gated calcium channel activity
spleen development
synaptic transmission
synaptic transmission, glutamatergic
T cell receptor signaling pathway
thymus development
transport
Gene Ontology Biological Process:
adult walking behavior
axon guidance
calcium ion transmembrane transport
cAMP metabolic process
cardiac conduction
cellular calcium ion homeostasis
detection of light stimulus involved in visual perception
gamma-aminobutyric acid secretion
gamma-aminobutyric acid signaling pathway
membrane depolarization
muscle fiber development
neuromuscular junction development
neuronal action potential propagation
Peyer's patch development
regulation of voltage-gated calcium channel activity
spleen development
synaptic transmission
synaptic transmission, glutamatergic
T cell receptor signaling pathway
thymus development
transport
Gene Ontology Molecular Function:
voltage-gated calcium channel activity
Gene Ontology Cellular Component:
cytoplasmic side of plasma membrane
cytosol
plasma membrane
synapse
voltage-gated calcium channel complex
Keywords:
3D-structure
Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Disease mutation
Epilepsy
Ion channel
Ion transport
Phosphoprotein
Reference proteome
SH3 domain
Transport
Voltage-gated channel
Interacts With:
P21579

Publication

PubMed ID:
9254841 11880487 17618603 14702039 15815621 15489334 9628818 10762541 19807924