Names & Taxonomy

Uniprot ID:
O00254
Entry Name:
PAR3_HUMAN
Status:
reviewed
Protein Names:
Proteinase-activated receptor 3 (PAR-3) (Coagulation factor II receptor-like 2) (Thrombin receptor-like 2)
Gene Names:
F2RL2 PAR3
Gene Names Primary:
F2RL2
Organism:
Homo sapiens (Human)

Structure

Length:
374
Sequence:
MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
Gene Ontology Go:
apical plasma membrane
extracellular region
integral component of plasma membrane
plasma membrane
phosphatidylinositol phospholipase C activity
thrombin receptor activity
blood coagulation
platelet activation
response to wounding
Gene Ontology Biological Process:
blood coagulation
platelet activation
response to wounding
Gene Ontology Molecular Function:
phosphatidylinositol phospholipase C activity
thrombin receptor activity
Gene Ontology Cellular Component:
apical plasma membrane
extracellular region
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Blood coagulation
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Hemostasis
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix
Interacts With:
P16333

Publication

PubMed ID:
9087410 14702039 17974005 15372022 15489334 9614115 10079109 16458856