Names & Taxonomy
- Uniprot ID:
- O00187
- Entry Name:
- MASP2_HUMAN
- Status:
- reviewed
- Protein Names:
- Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]
- Gene Names:
- MASP2
- Gene Names Primary:
- MASP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 686
- Sequence:
- MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
- Catalytic Activity:
- Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).
- Active Site:
- ACT_SITE 483 483 Charge relay system.; ACT_SITE 532 532 Charge relay system.; ACT_SITE 633 633 Charge relay system.
- Gene Ontology Go:
- extracellular exosome
extracellular region
calcium ion binding
calcium-dependent protein binding
complement component C4b binding
peptidase activity
serine-type endopeptidase activity
complement activation
complement activation, classical pathway
complement activation, lectin pathway
innate immune response - Gene Ontology Biological Process:
- complement activation
complement activation, classical pathway
complement activation, lectin pathway
innate immune response - Gene Ontology Molecular Function:
- calcium-dependent protein binding
calcium ion binding
complement component C4b binding
peptidase activity
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region - Keywords:
- 3D-structure
Alternative splicing
Autocatalytic cleavage
Calcium
Complement pathway
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Hydrolase
Hydroxylation
Immunity
Innate immunity
Metal-binding
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Sushi