Names & Taxonomy

Uniprot ID:
O00187
Entry Name:
MASP2_HUMAN
Status:
reviewed
Protein Names:
Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]
Gene Names:
MASP2
Gene Names Primary:
MASP2
Organism:
Homo sapiens (Human)

Structure

Length:
686
Sequence:
MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
Catalytic Activity:
Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).
Active Site:
ACT_SITE 483 483 Charge relay system.; ACT_SITE 532 532 Charge relay system.; ACT_SITE 633 633 Charge relay system.
Gene Ontology Go:
extracellular exosome
extracellular region
calcium ion binding
calcium-dependent protein binding
complement component C4b binding
peptidase activity
serine-type endopeptidase activity
complement activation
complement activation, classical pathway
complement activation, lectin pathway
innate immune response
Gene Ontology Biological Process:
complement activation
complement activation, classical pathway
complement activation, lectin pathway
innate immune response
Gene Ontology Molecular Function:
calcium-dependent protein binding
calcium ion binding
complement component C4b binding
peptidase activity
serine-type endopeptidase activity
Gene Ontology Cellular Component:
extracellular exosome
extracellular region
Keywords:
3D-structure
Alternative splicing
Autocatalytic cleavage
Calcium
Complement pathway
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Hydrolase
Hydroxylation
Immunity
Innate immunity
Metal-binding
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Sushi

Publication

PubMed ID:
9087411 10330290 10092804 14702039 16710414 8618346 11426320 10946292 15117939 15364579 16040602 12904520 16029433 17252003 25930971