Names & Taxonomy
- Uniprot ID:
- O00142
- Entry Name:
- KITM_HUMAN
- Status:
- reviewed
- Protein Names:
- Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (Mt-TK)
- Gene Names:
- TK2
- Gene Names Primary:
- TK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 265
- Sequence:
- MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs.
- Catalytic Activity:
- ATP + thymidine = ADP + thymidine 5'-phosphate.
- Active Site:
- ACT_SITE 133 133 Proton acceptor.
- Gene Ontology Go:
- mitochondrial matrix
ATP binding
deoxycytidine kinase activity
thymidine kinase activity
deoxycytidine metabolic process
DNA biosynthetic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
small molecule metabolic process
thymidine metabolic process - Gene Ontology Biological Process:
- deoxycytidine metabolic process
DNA biosynthetic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
small molecule metabolic process
thymidine metabolic process - Gene Ontology Molecular Function:
- ATP binding
deoxycytidine kinase activity
thymidine kinase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
- Keywords:
- ATP-binding
Alternative splicing
Complete proteome
DNA synthesis
Direct protein sequencing
Disease mutation
Kinase
Mitochondrion
Nucleotide-binding
Reference proteome
Transferase
Transit peptide