Names & Taxonomy

Uniprot ID:
O00142
Entry Name:
KITM_HUMAN
Status:
reviewed
Protein Names:
Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (Mt-TK)
Gene Names:
TK2
Gene Names Primary:
TK2
Organism:
Homo sapiens (Human)

Structure

Length:
265
Sequence:
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion.

Function

Function:
Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs.
Catalytic Activity:
ATP + thymidine = ADP + thymidine 5'-phosphate.
Active Site:
ACT_SITE 133 133 Proton acceptor.
Gene Ontology Go:
mitochondrial matrix
ATP binding
deoxycytidine kinase activity
thymidine kinase activity
deoxycytidine metabolic process
DNA biosynthetic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
small molecule metabolic process
thymidine metabolic process
Gene Ontology Biological Process:
deoxycytidine metabolic process
DNA biosynthetic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
small molecule metabolic process
thymidine metabolic process
Gene Ontology Molecular Function:
ATP binding
deoxycytidine kinase activity
thymidine kinase activity
Gene Ontology Cellular Component:
mitochondrial matrix
Keywords:
ATP-binding
Alternative splicing
Complete proteome
DNA synthesis
Direct protein sequencing
Disease mutation
Kinase
Mitochondrion
Nucleotide-binding
Reference proteome
Transferase
Transit peptide

Publication

PubMed ID:
9079672 9989599 14702039 15616553 25944712 11687801 12391347 15639197 15907288 25446393