Names & Taxonomy
- Uniprot ID:
- J7M2B1
- Entry Name:
- J7M2B1_HUMAN
- Status:
- unreviewed
- Protein Names:
- Tyrosine-protein kinase receptor (EC 2.7.10.1)
- Gene Names:
- EZR-ROS1 EZR-ROS1_E10;R34
- Gene Names Primary:
- EZR-ROS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 858
- Sequence:
- MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Gene Ontology Go:
- cytoplasm
cytoskeleton
extrinsic component of membrane
integral component of membrane
ATP binding
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Biological Process:
- transmembrane receptor protein tyrosine kinase signaling pathway
- Gene Ontology Molecular Function:
- ATP binding
transmembrane receptor protein tyrosine kinase activity - Gene Ontology Cellular Component:
- cytoplasm
cytoskeleton
extrinsic component of membrane
integral component of membrane - Keywords:
- Coiled coil
Membrane
Phosphoprotein
Receptor
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 22327623