Names & Taxonomy

Uniprot ID:
H7C4I3
Entry Name:
H7C4I3_HUMAN
Status:
unreviewed
Protein Names:
RuvB-like helicase (EC 3.6.4.12) (Fragment)
Gene Names:
RUVBL1
Gene Names Primary:
RUVBL1
Organism:
Homo sapiens (Human)

Structure

Length:
222
Sequence:
XKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTLHDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRSHDSMNMLVQLIWKPAAFKYHLIVSTQYDDSAPHRVGDCTQGILKLKSRPWKLPGVGSGHTWK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Catalytic Activity:
ATP + H(2)O = ADP + phosphate.
Gene Ontology Go:
nucleus
ATP binding
ATP-dependent 5'-3' DNA helicase activity
DNA recombination
DNA repair
regulation of transcription, DNA-templated
transcription, DNA-templated
Gene Ontology Biological Process:
DNA recombination
DNA repair
regulation of transcription, DNA-templated
transcription, DNA-templated
Gene Ontology Molecular Function:
ATP binding
ATP-dependent 5'-3' DNA helicase activity
Gene Ontology Cellular Component:
nucleus
Keywords:
ATP-binding
Complete proteome
DNA damage
DNA recombination
DNA repair
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Proteomics identification
Reference proteome
Transcription
Transcription regulation

Publication

PubMed ID:
16641997 21269460 25944712