Names & Taxonomy
- Uniprot ID:
- H7C3P4
- Entry Name:
- H7C3P4_HUMAN
- Status:
- unreviewed
- Protein Names:
- N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase)
- Gene Names:
- GNS hCG_1640559
- Gene Names Orf:
- hCG_1640559
- Gene Names Primary:
- GNS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 496
- Sequence:
- MDNYLLLQTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRGSVRTRRFSKHLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome
Function
- Catalytic Activity:
- Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Gene Ontology Go:
- lysosome
metal ion binding
N-acetylglucosamine-6-sulfatase activity
glycosaminoglycan metabolic process - Gene Ontology Biological Process:
- glycosaminoglycan metabolic process
- Gene Ontology Molecular Function:
- metal ion binding
N-acetylglucosamine-6-sulfatase activity - Gene Ontology Cellular Component:
- lysosome
- Keywords:
- Calcium
Complete proteome
Hydrolase
Lysosome
Metal-binding
Proteomics identification
Reference proteome