Names & Taxonomy
- Uniprot ID:
- B7Z3J6
- Entry Name:
- B7Z3J6_HUMAN
- Status:
- unreviewed
- Protein Names:
- Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45)
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 933
- Sequence:
- MGTQDPGNMGTGVPASEQISCAKEDPQVYCPEETGGTKDVQVTDCKSPEDSRPPKETDCCNPEDSGQLMVSYEGKAMGYQVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLRYLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHRTVIADQPICPLKFTVCLRRERQTVYQQVLSLERPSVLRSWNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDDAPGGLWNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQQVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCRLEFSLAWDMPRIMFGAKGQVHYRRYTRFFGQDGDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSALFNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLRDYGRFGYLEGQEYRMYNTYDVHFYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDKDHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILSRGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVRALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQEGLTWEGFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIWAMQLALQQQQHKKASWPKVKQGTGLRTGPMFGPKEAMANLSPE
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide.
- Catalytic Activity:
- D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine.
- Gene Ontology Go:
- endoplasmic reticulum membrane
Golgi membrane
integral component of membrane
glucosylceramidase activity
glucosylceramide catabolic process - Gene Ontology Biological Process:
- glucosylceramide catabolic process
- Gene Ontology Molecular Function:
- glucosylceramidase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
Golgi membrane
integral component of membrane - Keywords:
- Endoplasmic reticulum
Glycosidase
Golgi apparatus
Hydrolase
Lipid metabolism
Membrane