Names & Taxonomy

Uniprot ID:
B7Z3J6
Entry Name:
B7Z3J6_HUMAN
Status:
unreviewed
Protein Names:
Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45)
Organism:
Homo sapiens (Human)

Structure

Length:
933
Sequence:
MGTQDPGNMGTGVPASEQISCAKEDPQVYCPEETGGTKDVQVTDCKSPEDSRPPKETDCCNPEDSGQLMVSYEGKAMGYQVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLRYLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHRTVIADQPICPLKFTVCLRRERQTVYQQVLSLERPSVLRSWNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDDAPGGLWNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQQVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCRLEFSLAWDMPRIMFGAKGQVHYRRYTRFFGQDGDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSALFNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLRDYGRFGYLEGQEYRMYNTYDVHFYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDKDHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILSRGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVRALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQEGLTWEGFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIWAMQLALQQQQHKKASWPKVKQGTGLRTGPMFGPKEAMANLSPE

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide.
Catalytic Activity:
D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine.
Gene Ontology Go:
endoplasmic reticulum membrane
Golgi membrane
integral component of membrane
glucosylceramidase activity
glucosylceramide catabolic process
Gene Ontology Biological Process:
glucosylceramide catabolic process
Gene Ontology Molecular Function:
glucosylceramidase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
Golgi membrane
integral component of membrane
Keywords:
Endoplasmic reticulum
Glycosidase
Golgi apparatus
Hydrolase
Lipid metabolism
Membrane