Names & Taxonomy
- Uniprot ID:
- A0A024R968
- Entry Name:
- A0A024R968_HUMAN
- Status:
- unreviewed
- Protein Names:
- Calcium-transporting ATPase (EC 3.6.3.8)
- Gene Names:
- ATP2B4 hCG_18445
- Gene Names Orf:
- hCG_18445
- Gene Names Primary:
- ATP2B4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1205
- Sequence:
- MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKTSPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPEDENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKEEITKDAEGLDEIDHAEMELRRGQILWFRGLNRIQTQIKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEENPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
- Catalytic Activity:
- ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
- Gene Ontology Go:
- basolateral plasma membrane
integral component of membrane
neuron projection
plasma membrane
sperm principal piece
T-tubule
ATP binding
calcium-transporting ATPase activity
metal ion binding
calcium ion export
cellular calcium ion homeostasis
hippocampus development
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of cardiac muscle hypertrophy in response to stress
neural retina development
sperm motility
spermatogenesis - Gene Ontology Biological Process:
- calcium ion export
cellular calcium ion homeostasis
hippocampus development
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of cardiac muscle hypertrophy in response to stress
neural retina development
spermatogenesis
sperm motility - Gene Ontology Molecular Function:
- ATP binding
calcium-transporting ATPase activity
metal ion binding - Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of membrane
neuron projection
plasma membrane
sperm principal piece
T-tubule - Keywords:
- ATP-binding
Calcium
Calcium transport
Hydrolase
Ion transport
Membrane
Nucleotide-binding
Transmembrane
Transmembrane helix
Transport
Publication
- PubMed ID:
- 11181995