Names & Taxonomy

Uniprot ID:
B4DYZ4
Entry Name:
B4DYZ4_HUMAN
Status:
unreviewed
Protein Names:
Phosphoinositide phospholipase C (EC 3.1.4.11)
Organism:
Homo sapiens (Human)

Structure

Length:
1036
Sequence:
MKNKLQDPSNQKCGGRKKTVSFSSMPSEKKISSANDCINFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIIAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSSSAEAKSKRSLEAIEEKDLRWRWRVLSLAFCSDESTRSLQH

Function

Catalytic Activity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Gene Ontology Go:
intracellular
inositol 1,4,5 trisphosphate binding
phosphatidylinositol phospholipase C activity
signal transducer activity
intracellular signal transduction
lipid catabolic process
regulation of synaptic transmission, GABAergic
Gene Ontology Biological Process:
intracellular signal transduction
lipid catabolic process
regulation of synaptic transmission, GABAergic
Gene Ontology Molecular Function:
inositol 1,4,5 trisphosphate binding
phosphatidylinositol phospholipase C activity
signal transducer activity
Gene Ontology Cellular Component:
intracellular
Keywords:
Hydrolase
Lipid degradation
Lipid metabolism
Transducer