Names & Taxonomy

Uniprot ID:
B4DNJ7
Entry Name:
B4DNJ7_HUMAN
Status:
unreviewed
Protein Names:
Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)
Organism:
Homo sapiens (Human)

Structure

Length:
514
Sequence:
MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFLDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVFRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY

Function

Pathway:
Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
Catalytic Activity:
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.
Active Site:
ACT_SITE 331 331 Thioimidate intermediate.
Gene Ontology Go:
IMP dehydrogenase activity
metal ion binding
GMP biosynthetic process
Gene Ontology Biological Process:
GMP biosynthetic process
Gene Ontology Molecular Function:
IMP dehydrogenase activity
metal ion binding
Keywords:
GMP biosynthesis
Metal-binding
NAD
Oxidoreductase
Potassium
Purine biosynthesis