Names & Taxonomy
- Uniprot ID:
- A0A024R7M7
- Entry Name:
- A0A024R7M7_HUMAN
- Status:
- unreviewed
- Protein Names:
- Tyrosine-protein kinase (EC 2.7.10.2)
- Gene Names:
- JAK3 hCG_36874
- Gene Names Orf:
- hCG_36874
- Gene Names Primary:
- JAK3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1124
- Sequence:
- MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 949 949 Proton acceptor.
- Gene Ontology Go:
- cytoskeleton
cytosol
membrane
ATP binding
non-membrane spanning protein tyrosine kinase activity
cytokine-mediated signaling pathway
positive regulation of activated T cell proliferation
positive regulation of calcium ion transport
positive regulation of cytosolic calcium ion concentration
positive regulation of immune response
protein autophosphorylation
tyrosine phosphorylation of Stat5 protein - Gene Ontology Biological Process:
- cytokine-mediated signaling pathway
positive regulation of activated T cell proliferation
positive regulation of calcium ion transport
positive regulation of cytosolic calcium ion concentration
positive regulation of immune response
protein autophosphorylation
tyrosine phosphorylation of Stat5 protein - Gene Ontology Molecular Function:
- ATP binding
non-membrane spanning protein tyrosine kinase activity - Gene Ontology Cellular Component:
- cytoskeleton
cytosol
membrane - Keywords:
- ATP-binding
Kinase
Nucleotide-binding
Transferase
Tyrosine-protein kinase
Publication
- PubMed ID:
- 11181995