Names & Taxonomy

Uniprot ID:
A0A024R474
Entry Name:
A0A024R474_HUMAN
Status:
unreviewed
Protein Names:
Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 1, isoform CRA_b
Gene Names:
SLC11A1 hCG_16301
Gene Names Orf:
hCG_16301
Gene Names Primary:
SLC11A1
Organism:
Homo sapiens (Human)

Structure

Length:
550
Sequence:
MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG

Function

Gene Ontology Go:
cell outer membrane
endosome membrane
integral component of membrane
late endosome
lysosome
phagocytic vesicle membrane
manganese ion transmembrane transporter activity
activation of protein kinase activity
antigen processing and presentation of peptide antigen
cellular iron ion homeostasis
defense response to Gram-negative bacterium
defense response to protozoan
divalent metal ion export
inflammatory response
interleukin-2 production
interleukin-3 production
iron ion transport
L-arginine import
macrophage activation
MHC class II biosynthetic process
mRNA stabilization
multicellular organismal iron ion homeostasis
negative regulation of cytokine production
nitrite transport
phagocytosis
positive regulation of dendritic cell antigen processing and presentation
positive regulation of interferon-gamma production
positive regulation of phagocytosis
positive regulation of T-helper 1 type immune response
positive regulation of transcription from RNA polymerase II promoter
protein import into nucleus, translocation
respiratory burst
response to interferon-gamma
response to lipopolysaccharide
T cell cytokine production
T cell proliferation involved in immune response
vacuolar acidification
wound healing
Gene Ontology Biological Process:
activation of protein kinase activity
antigen processing and presentation of peptide antigen
cellular iron ion homeostasis
defense response to Gram-negative bacterium
defense response to protozoan
divalent metal ion export
inflammatory response
interleukin-2 production
interleukin-3 production
iron ion transport
L-arginine import
macrophage activation
MHC class II biosynthetic process
mRNA stabilization
multicellular organismal iron ion homeostasis
negative regulation of cytokine production
nitrite transport
phagocytosis
positive regulation of dendritic cell antigen processing and presentation
positive regulation of interferon-gamma production
positive regulation of phagocytosis
positive regulation of T-helper 1 type immune response
positive regulation of transcription from RNA polymerase II promoter
protein import into nucleus, translocation
respiratory burst
response to interferon-gamma
response to lipopolysaccharide
T cell cytokine production
T cell proliferation involved in immune response
vacuolar acidification
wound healing
Gene Ontology Molecular Function:
manganese ion transmembrane transporter activity
Gene Ontology Cellular Component:
cell outer membrane
endosome membrane
integral component of membrane
late endosome
lysosome
phagocytic vesicle membrane
Keywords:
Membrane
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11181995