Names & Taxonomy
- Uniprot ID:
- A0A024R474
- Entry Name:
- A0A024R474_HUMAN
- Status:
- unreviewed
- Protein Names:
- Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 1, isoform CRA_b
- Gene Names:
- SLC11A1 hCG_16301
- Gene Names Orf:
- hCG_16301
- Gene Names Primary:
- SLC11A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 550
- Sequence:
- MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG
Function
- Gene Ontology Go:
- cell outer membrane
endosome membrane
integral component of membrane
late endosome
lysosome
phagocytic vesicle membrane
manganese ion transmembrane transporter activity
activation of protein kinase activity
antigen processing and presentation of peptide antigen
cellular iron ion homeostasis
defense response to Gram-negative bacterium
defense response to protozoan
divalent metal ion export
inflammatory response
interleukin-2 production
interleukin-3 production
iron ion transport
L-arginine import
macrophage activation
MHC class II biosynthetic process
mRNA stabilization
multicellular organismal iron ion homeostasis
negative regulation of cytokine production
nitrite transport
phagocytosis
positive regulation of dendritic cell antigen processing and presentation
positive regulation of interferon-gamma production
positive regulation of phagocytosis
positive regulation of T-helper 1 type immune response
positive regulation of transcription from RNA polymerase II promoter
protein import into nucleus, translocation
respiratory burst
response to interferon-gamma
response to lipopolysaccharide
T cell cytokine production
T cell proliferation involved in immune response
vacuolar acidification
wound healing - Gene Ontology Biological Process:
- activation of protein kinase activity
antigen processing and presentation of peptide antigen
cellular iron ion homeostasis
defense response to Gram-negative bacterium
defense response to protozoan
divalent metal ion export
inflammatory response
interleukin-2 production
interleukin-3 production
iron ion transport
L-arginine import
macrophage activation
MHC class II biosynthetic process
mRNA stabilization
multicellular organismal iron ion homeostasis
negative regulation of cytokine production
nitrite transport
phagocytosis
positive regulation of dendritic cell antigen processing and presentation
positive regulation of interferon-gamma production
positive regulation of phagocytosis
positive regulation of T-helper 1 type immune response
positive regulation of transcription from RNA polymerase II promoter
protein import into nucleus, translocation
respiratory burst
response to interferon-gamma
response to lipopolysaccharide
T cell cytokine production
T cell proliferation involved in immune response
vacuolar acidification
wound healing - Gene Ontology Molecular Function:
- manganese ion transmembrane transporter activity
- Gene Ontology Cellular Component:
- cell outer membrane
endosome membrane
integral component of membrane
late endosome
lysosome
phagocytic vesicle membrane - Keywords:
- Membrane
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 11181995