Names & Taxonomy
- Uniprot ID:
- A8K4H7
- Entry Name:
- A8K4H7_HUMAN
- Status:
- unreviewed
- Protein Names:
- Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase)
- Gene Names:
- PPAT hCG_2027246
- Gene Names Orf:
- hCG_2027246
- Gene Names Primary:
- PPAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 517
- Sequence:
- MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEAPTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFLSIGARYYREVLPGEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIEAPVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGINIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKEKKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW
Function
- Pathway:
- Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.
- Catalytic Activity:
- 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O.
- Cofactor:
- COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49883;
- Active Site:
- ACT_SITE 12 12 For GATase activity.
- Gene Ontology Go:
- amidophosphoribosyltransferase activity
iron-sulfur cluster binding
metal ion binding
'de novo' IMP biosynthetic process
cellular response to drug
cellular response to insulin stimulus
G1/S transition of mitotic cell cycle
glutamine catabolic process
kidney development
lactation
maternal process involved in female pregnancy
nucleoside metabolic process
organ regeneration
protein homotetramerization
purine nucleobase biosynthetic process - Gene Ontology Biological Process:
- 'de novo' IMP biosynthetic process
cellular response to drug
cellular response to insulin stimulus
G1/S transition of mitotic cell cycle
glutamine catabolic process
kidney development
lactation
maternal process involved in female pregnancy
nucleoside metabolic process
organ regeneration
protein homotetramerization
purine nucleobase biosynthetic process - Gene Ontology Molecular Function:
- amidophosphoribosyltransferase activity
iron-sulfur cluster binding
metal ion binding - Keywords:
- Glycosyltransferase
Iron
Iron-sulfur
Metal-binding
Purine biosynthesis
Transferase
Publication
- PubMed ID:
- 11181995