Names & Taxonomy

Uniprot ID:
A8K4H7
Entry Name:
A8K4H7_HUMAN
Status:
unreviewed
Protein Names:
Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase)
Gene Names:
PPAT hCG_2027246
Gene Names Orf:
hCG_2027246
Gene Names Primary:
PPAT
Organism:
Homo sapiens (Human)

Structure

Length:
517
Sequence:
MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEAPTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFLSIGARYYREVLPGEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIEAPVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGINIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKEKKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW

Function

Pathway:
Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.
Catalytic Activity:
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O.
Cofactor:
COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49883;
Active Site:
ACT_SITE 12 12 For GATase activity.
Gene Ontology Go:
amidophosphoribosyltransferase activity
iron-sulfur cluster binding
metal ion binding
'de novo' IMP biosynthetic process
cellular response to drug
cellular response to insulin stimulus
G1/S transition of mitotic cell cycle
glutamine catabolic process
kidney development
lactation
maternal process involved in female pregnancy
nucleoside metabolic process
organ regeneration
protein homotetramerization
purine nucleobase biosynthetic process
Gene Ontology Biological Process:
'de novo' IMP biosynthetic process
cellular response to drug
cellular response to insulin stimulus
G1/S transition of mitotic cell cycle
glutamine catabolic process
kidney development
lactation
maternal process involved in female pregnancy
nucleoside metabolic process
organ regeneration
protein homotetramerization
purine nucleobase biosynthetic process
Gene Ontology Molecular Function:
amidophosphoribosyltransferase activity
iron-sulfur cluster binding
metal ion binding
Keywords:
Glycosyltransferase
Iron
Iron-sulfur
Metal-binding
Purine biosynthesis
Transferase

Publication

PubMed ID:
11181995