Names & Taxonomy
- Uniprot ID:
- A5YKK6
- Entry Name:
- CNOT1_HUMAN
- Status:
- reviewed
- Protein Names:
- CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)
- Gene Names:
- CNOT1 CDC39 KIAA1007 NOT1 AD-005
- Gene Names Orf:
- AD-005
- Gene Names Primary:
- CNOT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2376
- Sequence:
- MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLITKPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVSTMVTTSTTTTVAKTVTVTRPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPKKDVKQPEELPPITTTTTSTTPATNTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHVTEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, P-body
Function
- Function:
- Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.
- Gene Ontology Go:
- CCR4-NOT complex
CCR4-NOT core complex
cytoplasm
cytoplasmic mRNA processing body
cytosol
extracellular space
intracellular membrane-bounded organelle
membrane
nucleus
peroxisomal membrane
armadillo repeat domain binding
estrogen receptor binding
poly(A) RNA binding
protein complex scaffold
protein domain specific binding
retinoic acid receptor binding
gene expression
gene silencing by miRNA
multicellular organism development
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of retinoic acid receptor signaling pathway
negative regulation of transcription from RNA polymerase II promoter
negative regulation of translation
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of cytoplasmic mRNA processing body assembly
positive regulation of mRNA catabolic process
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
regulation of stem cell population maintenance
RNA phosphodiester bond hydrolysis, exonucleolytic
transcription, DNA-templated - Gene Ontology Biological Process:
- gene expression
gene silencing by miRNA
multicellular organism development
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of retinoic acid receptor signaling pathway
negative regulation of transcription from RNA polymerase II promoter
negative regulation of translation
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of cytoplasmic mRNA processing body assembly
positive regulation of mRNA catabolic process
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
regulation of stem cell population maintenance
RNA phosphodiester bond hydrolysis, exonucleolytic
transcription, DNA-templated - Gene Ontology Molecular Function:
- armadillo repeat domain binding
estrogen receptor binding
poly(A) RNA binding
protein complex scaffold
protein domain specific binding
retinoic acid receptor binding - Gene Ontology Cellular Component:
- CCR4-NOT complex
CCR4-NOT core complex
cytoplasm
cytoplasmic mRNA processing body
cytosol
extracellular space
intracellular membrane-bounded organelle
membrane
nucleus
peroxisomal membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Developmental protein
Nucleus
Polymorphism
RNA-mediated gene silencing
Reference proteome
Repressor
Transcription
Transcription regulation
Translation regulation - Interacts With:
- Q9UKZ1; Q9NZN8; O75175; Q9ULM6; Q96LI5; Q9UIV1; Q9UFF9; Q8NDV7; Q9UPQ9; Q9HCJ0; P50616; P22893