Names & Taxonomy
- Uniprot ID:
- Q9Y6M7
- Entry Name:
- S4A7_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7)
- Gene Names:
- SLC4A7 BT NBC2 NBC2B NBC3 NBCn1 SBC2 SLC4A6
- Gene Names Primary:
- SLC4A7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1214
- Sequence:
- MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWIISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFEDEPRKKYVDAETSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane
Function
- Function:
- Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=24 mM for external sodium
- Enzyme Regulation:
- ENZYME REGULATION: Transporter activity is regulated by CA2/carbonic anhydrase 2, cAMP and PKA. Insensitive to stilbene derivatives. PubMed:10347222 states it is inhibited by 5-(N-ethyl-N-isopropyl)-amiloride (EIPA).
- Cross Reference Drug Bank:
- DB01390
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
cytoplasmic vesicle
integral component of membrane
plasma membrane
stereocilium
synapse
anion transmembrane transporter activity
inorganic anion exchanger activity
sodium:bicarbonate symporter activity
anion transmembrane transport
auditory receptor cell development
bicarbonate transport
ion transport
sodium ion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- anion transmembrane transport
auditory receptor cell development
bicarbonate transport
ion transport
sodium ion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- anion transmembrane transporter activity
inorganic anion exchanger activity
sodium:bicarbonate symporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
cytoplasmic vesicle
integral component of membrane
plasma membrane
stereocilium
synapse - Keywords:
- Alternative splicing
Cell membrane
Cell projection
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport