Names & Taxonomy

Uniprot ID:
Q9Y6K0
Entry Name:
CEPT1_HUMAN
Status:
reviewed
Protein Names:
Choline/ethanolaminephosphotransferase 1 (hCEPT1) (EC 2.7.8.1) (EC 2.7.8.2)
Gene Names:
CEPT1 PRO1101
Gene Names Orf:
PRO1101
Gene Names Primary:
CEPT1
Organism:
Homo sapiens (Human)

Structure

Length:
416
Sequence:
MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAGRSLLEPLMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFGIIDVTEVQIFIIIMHLLAVIGGPPFWQSMIPVLNIQMKIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKVSTAHSNHH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
Pathway:
Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.; Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
Catalytic Activity:
CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=37 uM for CDP-choline
Cross Reference Drug Bank:
DB00122
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
nuclear membrane
diacylglycerol cholinephosphotransferase activity
ethanolaminephosphotransferase activity
metal ion binding
CDP-choline pathway
glycerophospholipid biosynthetic process
lipid metabolic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
CDP-choline pathway
glycerophospholipid biosynthetic process
lipid metabolic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
diacylglycerol cholinephosphotransferase activity
ethanolaminephosphotransferase activity
metal ion binding
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
nuclear membrane
Keywords:
Complete proteome
Endoplasmic reticulum
Glycoprotein
Lipid biosynthesis
Lipid metabolism
Magnesium
Manganese
Membrane
Metal-binding
Nucleus
Phospholipid biosynthesis
Phospholipid metabolism
Phosphoprotein
Reference proteome
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10191259 16710414 15489334 17974005 10893425 12216837 12221122 18691976 20068231 25944712