Names & Taxonomy
- Uniprot ID:
- Q9Y6K0
- Entry Name:
- CEPT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Choline/ethanolaminephosphotransferase 1 (hCEPT1) (EC 2.7.8.1) (EC 2.7.8.2)
- Gene Names:
- CEPT1 PRO1101
- Gene Names Orf:
- PRO1101
- Gene Names Primary:
- CEPT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 416
- Sequence:
- MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAGRSLLEPLMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFGIIDVTEVQIFIIIMHLLAVIGGPPFWQSMIPVLNIQMKIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKVSTAHSNHH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
- Pathway:
- Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.; Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
- Catalytic Activity:
- CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=37 uM for CDP-choline
- Cross Reference Drug Bank:
- DB00122
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
nuclear membrane
diacylglycerol cholinephosphotransferase activity
ethanolaminephosphotransferase activity
metal ion binding
CDP-choline pathway
glycerophospholipid biosynthetic process
lipid metabolic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- CDP-choline pathway
glycerophospholipid biosynthetic process
lipid metabolic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- diacylglycerol cholinephosphotransferase activity
ethanolaminephosphotransferase activity
metal ion binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
nuclear membrane - Keywords:
- Complete proteome
Endoplasmic reticulum
Glycoprotein
Lipid biosynthesis
Lipid metabolism
Magnesium
Manganese
Membrane
Metal-binding
Nucleus
Phospholipid biosynthesis
Phospholipid metabolism
Phosphoprotein
Reference proteome
Transferase
Transmembrane
Transmembrane helix