Names & Taxonomy
- Uniprot ID:
- Q9Y6A1
- Entry Name:
- POMT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein O-mannosyl-transferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1)
- Gene Names:
- POMT1
- Gene Names Primary:
- POMT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 747
- Sequence:
- MWGFLKRPVVVTADINLSLVALTGMGLLSRLWRLTYPRAVVFDEVYYGQYISFYMKQIFFLDDSGPPFGHMVLALGGYLGGFDGNFLWNRIGAEYSSNVPVWSLRLLPALAGALSVPMAYQIVLELHFSHCAAMGAALLMLIENALITQSRLMLLESVLIFFNLLAVLSYLKFFNCQKHSPFSLSWWFWLTLTGVACSCAVGIKYMGVFTYVLVLGVAAVHAWHLLGDQTLSNVGADVQCCMRPACMGQMQMSQGVCVFCHLLARAVALLVIPVVLYLLFFYVHLILVFRSGPHDQIMSSAFQASLEGGLARITQGQPLEVAFGSQVTLRNVFGKPVPCWLHSHQDTYPMIYENGRGSSHQQQVTCYPFKDVNNWWIVKDPRRHQLVVSSPPRPVRHGDMVQLVHGMTTRSLNTHDVAAPLSPHSQEVSCYIDYNISMPAQNLWRLEIVNRGSDTDVWKTILSEVRFVHVNTSAVLKLSGAHLPDWGYRQLEIVGEKLSRGYHGSTVWNVEEHRYGASQEQRERERELHSPAQVDVSRNLSFMARFSELQWRMLALRSDDSEHKYSSSPLEWVTLDTNIAYWLHPRTSAQIHLLGNIVIWVSGSLALAIYALLSLWYLLRRRRNVHDLPQDAWLRWVLAGALCAGGWAVNYLPFFLMEKTLFLYHYLPALTFQILLLPVVLQHISDHLCRSQLQRSIFSALVVAWYSSACHVSNTLRPLTYGDKSLSPHELKALRWKDSWDILIRKH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.
- Pathway:
- Protein modification; protein glycosylation.
- Catalytic Activity:
- Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.
- Enzyme Regulation:
- ENZYME REGULATION: Slightly activated by Mg(2+) and inhibited by both Ca(+) and Mn(2+). EDTA ha no effect on activity in vitro.
- Gene Ontology Go:
- acrosomal vesicle
dolichyl-phosphate-mannose-protein mannosyltransferase complex
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
sarcoplasmic reticulum
dolichyl-phosphate-mannose-protein mannosyltransferase activity
mannosyltransferase activity
metal ion binding
carbohydrate metabolic process
cell wall mannoprotein biosynthetic process
chain elongation of O-linked mannose residue
extracellular matrix organization
multicellular organism development
protein O-linked glycosylation
protein O-linked mannosylation
regulation of endoplasmic reticulum unfolded protein response - Gene Ontology Biological Process:
- carbohydrate metabolic process
cell wall mannoprotein biosynthetic process
chain elongation of O-linked mannose residue
extracellular matrix organization
multicellular organism development
protein O-linked glycosylation
protein O-linked mannosylation
regulation of endoplasmic reticulum unfolded protein response - Gene Ontology Molecular Function:
- dolichyl-phosphate-mannose-protein mannosyltransferase activity
mannosyltransferase activity
metal ion binding - Gene Ontology Cellular Component:
- acrosomal vesicle
dolichyl-phosphate-mannose-protein mannosyltransferase complex
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
sarcoplasmic reticulum - Keywords:
- Alternative splicing
Complete proteome
Congenital muscular dystrophy
Disease mutation
Dystroglycanopathy
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Limb-girdle muscular dystrophy
Lissencephaly
Membrane
Metal-binding
Polymorphism
Reference proteome
Repeat
Transferase
Transmembrane
Transmembrane helix