Names & Taxonomy
- Uniprot ID:
- Q9Y694
- Entry Name:
- S22A7_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 22 member 7 (Novel liver transporter) (Organic anion transporter 2) (hOAT2)
- Gene Names:
- SLC22A7 NLT OAT2
- Gene Names Primary:
- SLC22A7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 548
- Sequence:
- MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEEMPMKQVQN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane
Function
- Function:
- Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=713 nM for prostaglandin E2
- Cross Reference Drug Bank:
- DB00945 DB00437 DB00345 DB00887 DB00456 DB01326 DB01329 DB00493 DB02659 DB00501 DB01211 DB01160 DB00917 DB01248 DB00584 DB00199 DB00544 DB01004 DB01016 DB00328 DB01009 DB00563 DB01017 DB01303 DB00595 DB00175 DB01032 DB01045 DB00936 DB00624 DB00759 DB00277 DB00313 DB00943 DB00495
- Gene Ontology Go:
- basolateral plasma membrane
integral component of plasma membrane
membrane
plasma membrane
sodium-independent organic anion transmembrane transporter activity
organic anion transport
transmembrane transport - Gene Ontology Biological Process:
- organic anion transport
transmembrane transport - Gene Ontology Molecular Function:
- sodium-independent organic anion transmembrane transporter activity
- Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport