Names & Taxonomy

Uniprot ID:
Q9Y678
Entry Name:
COPG1_HUMAN
Status:
reviewed
Protein Names:
Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)
Gene Names:
COPG1 COPG
Gene Names Primary:
COPG1
Organism:
Homo sapiens (Human)

Structure

Length:
874
Sequence:
MLKKFDKKDEESGGGSNPFQHLEKSAVLQEARVFNETPINPRKCAHILTKILYLINQGEHLGTTEATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDVIIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNEAQEAASSDNIMVQYHALGLLYHVRKNDRLAVNKMISKVTRHGLKSPFAYCMMIRVASKQLEEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVNLPGCSAKELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRLMKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNFLFTMLREEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKTTNPSKYIRFIYNRVVLEHEEVRAGAVSALAKFGAQNEEMLPSILVLLKRCVMDDDNEVRDRATFYLNVLEQKQKALNAGYILNGLTVSIPGLERALQQYTLEPSEKPFDLKSVPLATAPMAEQRTESTPITAVKQPEKVAATRQEIFQEQLAAVPEFRGLGPLFKSSPEPVALTESETEYVIRCTKHTFTNHMVFQFDCTNTLNDQTLENVTVQMEPTEAYEVLCYVPARSLPYNQPGTCYTLVALPKEDPTAVACTFSCMMKFTVKDCDPTTGETDDEGYEDEYVLEDLEVTVADHIQKVMKLNFEAAWDEVGDEFEKEETFTLSTIKTLEEAVGNIVKFLGMHPCERSDKVPDNKNTHTLLLAGVFRGGHDILVRSRLLLLDTVTMQVTARSLEELPVDIILASVG
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity).
Gene Ontology Go:
COPI vesicle coat
cytosol
Golgi apparatus
Golgi membrane
transport vesicle
structural molecule activity
cellular protein metabolic process
COPI coating of Golgi vesicle
ER to Golgi vesicle-mediated transport
establishment of Golgi localization
intracellular protein transport
membrane organization
organelle transport along microtubule
post-translational protein modification
protein N-linked glycosylation via asparagine
retrograde vesicle-mediated transport, Golgi to ER
Gene Ontology Biological Process:
cellular protein metabolic process
COPI coating of Golgi vesicle
ER to Golgi vesicle-mediated transport
establishment of Golgi localization
intracellular protein transport
membrane organization
organelle transport along microtubule
post-translational protein modification
protein N-linked glycosylation via asparagine
retrograde vesicle-mediated transport, Golgi to ER
Gene Ontology Molecular Function:
structural molecule activity
Gene Ontology Cellular Component:
COPI vesicle coat
cytosol
Golgi apparatus
Golgi membrane
transport vesicle
Keywords:
3D-structure
Complete proteome
Cytoplasm
Cytoplasmic vesicle
ER-Golgi transport
Golgi apparatus
Membrane
Polymorphism
Protein transport
Reference proteome
Repeat
Transport
Interacts With:
Q92538; Q96RS6; Q9NTJ5

Publication

PubMed ID:
11056392 10931946 14702039 15489334 20674546 21269460 24275569 25944712 14690497