Names & Taxonomy
- Uniprot ID:
- Q9Y5Y4
- Entry Name:
- PD2R2_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)
- Gene Names:
- PTGDR2 CRTH2 DL1R GPR44
- Gene Names Primary:
- PTGDR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 395
- Sequence:
- MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
- Cross Reference Drug Bank:
- DB00328 DB00605
- Gene Ontology Go:
- integral component of plasma membrane
intracellular
neuron projection
plasma membrane
G-protein coupled receptor activity
neuropeptide binding
prostaglandin D receptor activity
prostaglandin F receptor activity
prostaglandin J receptor activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
calcium-mediated signaling
chemotaxis
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
immune response
negative regulation of male germ cell proliferation
neuropeptide signaling pathway
positive regulation of G-protein coupled receptor protein signaling pathway
synaptic transmission - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
calcium-mediated signaling
chemotaxis
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
immune response
negative regulation of male germ cell proliferation
neuropeptide signaling pathway
positive regulation of G-protein coupled receptor protein signaling pathway
synaptic transmission - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
neuropeptide binding
prostaglandin D receptor activity
prostaglandin F receptor activity
prostaglandin J receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
intracellular
neuron projection
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix