Names & Taxonomy

Uniprot ID:
Q9Y5Y0
Entry Name:
FLVC1_HUMAN
Status:
reviewed
Protein Names:
Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (hFLVCR)
Gene Names:
FLVCR1 FLVCR
Gene Names Primary:
FLVCR1
Organism:
Homo sapiens (Human)

Structure

Length:
555
Sequence:
MARPDDEEGAAVAPGHPLAKGYLPLPRGAPVGKESVELQNGPKAGTFPVNGAPRDSLAAASGVLGGPQTPLAPEEETQARLLPAGAGAETPGAESSPLPLTALSPRRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWIKCGSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQNDTNLLACNISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTALIKSDLRRHNINIGITNVDVKAIPADSPTDQEPKTVMLSKQSESAI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cell membrane

Function

Function:
Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells.; Isoform 2: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.
Gene Ontology Go:
integral component of plasma membrane
mitochondrial membrane
mitochondrion
plasma membrane
heme transporter activity
transporter activity
blood vessel development
cellular iron ion homeostasis
embryonic digit morphogenesis
embryonic skeletal system morphogenesis
erythrocyte differentiation
erythrocyte maturation
head morphogenesis
heme export
heme transport
in utero embryonic development
mitochondrial transport
multicellular organism development
multicellular organism growth
regulation of organ growth
spleen development
transmembrane transport
transport
Gene Ontology Biological Process:
blood vessel development
cellular iron ion homeostasis
embryonic digit morphogenesis
embryonic skeletal system morphogenesis
erythrocyte differentiation
erythrocyte maturation
head morphogenesis
heme export
heme transport
in utero embryonic development
mitochondrial transport
multicellular organism development
multicellular organism growth
regulation of organ growth
spleen development
transmembrane transport
transport
Gene Ontology Molecular Function:
heme transporter activity
transporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
mitochondrial membrane
mitochondrion
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Erythrocyte maturation
Glycoprotein
Membrane
Mitochondrion
Neurodegeneration
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Retinitis pigmentosa
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
10400745 14702039 15489334 11943475 15369674 16439531 18669648 19413330 19690332 20610401 20068231 21406692 23187127 21070897 21267618