Names & Taxonomy
- Uniprot ID:
- Q9Y4W6
- Entry Name:
- AFG32_HUMAN
- Status:
- reviewed
- Protein Names:
- AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein)
- Gene Names:
- AFG3L2
- Gene Names Primary:
- AFG3L2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 797
- Sequence:
- MAHRCLRLWGRGGCWPRGLQQLLVPGGVGPGEQPCLRTLYRFVTTQARASRNSLLTDIIAAYQRFCSRPPKGFEKYFPNGKNGKKASEPKEVMGEKKESKPAATTRSSGGGGGGGGKRGGKKDDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLLKRSGREITWKDFVNNYLSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDWNKEREKEKEEPPGEKVAN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion membrane
Function
- Function:
- ATP-dependent protease which is essential for axonal development.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 575 575
- Cross Reference Drug Bank:
- DB00171
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
mitochondrion
ATP binding
ATP-dependent peptidase activity
metalloendopeptidase activity
metallopeptidase activity
unfolded protein binding
zinc ion binding
axonogenesis
cristae formation
mitochondrial fusion
mitochondrial protein processing
muscle fiber development
myelination
nerve development
neuromuscular junction development
protein complex assembly
protein import into mitochondrial intermembrane space
regulation of multicellular organism growth
righting reflex - Gene Ontology Biological Process:
- axonogenesis
cristae formation
mitochondrial fusion
mitochondrial protein processing
muscle fiber development
myelination
nerve development
neuromuscular junction development
protein complex assembly
protein import into mitochondrial intermembrane space
regulation of multicellular organism growth
righting reflex - Gene Ontology Molecular Function:
- ATP binding
ATP-dependent peptidase activity
metalloendopeptidase activity
metallopeptidase activity
unfolded protein binding
zinc ion binding - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
mitochondrion - Keywords:
- 3D-structure
ATP-binding
Complete proteome
Disease mutation
Hydrolase
Membrane
Metal-binding
Metalloprotease
Mitochondrion
Neurodegeneration
Nucleotide-binding
Protease
Reference proteome
Spinocerebellar ataxia
Transmembrane
Transmembrane helix
Zinc