Names & Taxonomy
- Uniprot ID:
- Q9Y4D2
- Entry Name:
- DGLA_HUMAN
- Status:
- reviewed
- Protein Names:
- Sn1-specific diacylglycerol lipase alpha (DGL-alpha) (EC 3.1.1.-) (Neural stem cell-derived dendrite regulator)
- Gene Names:
- DAGLA C11orf11 KIAA0659 NSDDR
- Gene Names Primary:
- DAGLA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1042
- Sequence:
- MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFALAAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRNSSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIRTSTPTGHGASPAKQDELVISAR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=154.7 uM for diacylglycerol
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
- Active Site:
- ACT_SITE 472 472 Charge relay system.
- Gene Ontology Go:
- integral component of membrane
plasma membrane
varicosity
hydrolase activity
metal ion binding
arachidonic acid metabolic process
blood coagulation
diacylglycerol catabolic process
endocannabinoid signaling pathway
neuroblast proliferation
neurotransmitter biosynthetic process
platelet activation - Gene Ontology Biological Process:
- arachidonic acid metabolic process
blood coagulation
diacylglycerol catabolic process
endocannabinoid signaling pathway
neuroblast proliferation
neurotransmitter biosynthetic process
platelet activation - Gene Ontology Molecular Function:
- hydrolase activity
metal ion binding - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane
varicosity - Keywords:
- Calcium
Cell membrane
Complete proteome
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Membrane
Metal-binding
Neurodegeneration
Phosphoprotein
Polymorphism
Reference proteome
Spinocerebellar ataxia
Transmembrane
Transmembrane helix