Names & Taxonomy
- Uniprot ID:
- Q9Y3R4
- Entry Name:
- NEUR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (N-acetyl-alpha-neuraminidase 2)
- Gene Names:
- NEU2
- Gene Names Primary:
- NEU2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 380
- Sequence:
- MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.
- Catalytic Activity:
- Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
- Active Site:
- ACT_SITE 46 46 Proton acceptor.; ACT_SITE 334 334 Nucleophile.; ACT_SITE 355 355
- Cross Reference Drug Bank:
- DB00198 DB00558
- Gene Ontology Go:
- cytoplasm
cytosol
intracellular membrane-bounded organelle
membrane
exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
ganglioside catabolic process
glycosphingolipid metabolic process
oligosaccharide catabolic process
positive regulation of myoblast differentiation
positive regulation of myotube differentiation
post-translational protein modification
protein N-linked glycosylation via asparagine
response to ethanol
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Biological Process:
- cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
ganglioside catabolic process
glycosphingolipid metabolic process
oligosaccharide catabolic process
positive regulation of myoblast differentiation
positive regulation of myotube differentiation
post-translational protein modification
protein N-linked glycosylation via asparagine
response to ethanol
small molecule metabolic process
sphingolipid metabolic process - Gene Ontology Molecular Function:
- exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
intracellular membrane-bounded organelle
membrane - Keywords:
- 3D-structure
Carbohydrate metabolism
Complete proteome
Cytoplasm
Glycosidase
Hydrolase
Lipid degradation
Lipid metabolism
Polymorphism
Reference proteome
Repeat - Interacts With:
- Q7Z3S9