Names & Taxonomy

Uniprot ID:
Q9Y3R4
Entry Name:
NEUR2_HUMAN
Status:
reviewed
Protein Names:
Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (N-acetyl-alpha-neuraminidase 2)
Gene Names:
NEU2
Gene Names Primary:
NEU2
Organism:
Homo sapiens (Human)

Structure

Length:
380
Sequence:
MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.
Catalytic Activity:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Active Site:
ACT_SITE 46 46 Proton acceptor.; ACT_SITE 334 334 Nucleophile.; ACT_SITE 355 355
Cross Reference Drug Bank:
DB00198 DB00558
Gene Ontology Go:
cytoplasm
cytosol
intracellular membrane-bounded organelle
membrane
exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
ganglioside catabolic process
glycosphingolipid metabolic process
oligosaccharide catabolic process
positive regulation of myoblast differentiation
positive regulation of myotube differentiation
post-translational protein modification
protein N-linked glycosylation via asparagine
response to ethanol
small molecule metabolic process
sphingolipid metabolic process
Gene Ontology Biological Process:
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
ganglioside catabolic process
glycosphingolipid metabolic process
oligosaccharide catabolic process
positive regulation of myoblast differentiation
positive regulation of myotube differentiation
post-translational protein modification
protein N-linked glycosylation via asparagine
response to ethanol
small molecule metabolic process
sphingolipid metabolic process
Gene Ontology Molecular Function:
exo-alpha-(2->3)-sialidase activity
exo-alpha-(2->6)-sialidase activity
exo-alpha-(2->8)-sialidase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
intracellular membrane-bounded organelle
membrane
Keywords:
3D-structure
Carbohydrate metabolism
Complete proteome
Cytoplasm
Glycosidase
Hydrolase
Lipid degradation
Lipid metabolism
Polymorphism
Reference proteome
Repeat
Interacts With:
Q7Z3S9

Publication

PubMed ID:
10191093 15815621 15489334 14613940 22228546 15501818 17426694