Names & Taxonomy
- Uniprot ID:
- Q9Y2U5
- Entry Name:
- M3K2_HUMAN
- Status:
- reviewed
- Protein Names:
- Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
- Gene Names:
- MAP3K2 MAPKKK2 MEKK2
- Gene Names Primary:
- MAP3K2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 619
- Sequence:
- MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Activated by phosphorylation on Thr-524.
- Active Site:
- ACT_SITE 483 483 Proton acceptor.
- Cross Reference Drug Bank:
- DB06616
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
ATP binding
MAP kinase kinase kinase activity
metal ion binding
protein kinase activity
protein kinase binding
protein serine/threonine kinase activity
activation of JUN kinase activity
activation of MAPK activity
cellular response to mechanical stimulus
positive regulation of transcription, DNA-templated
protein phosphorylation
regulation of apoptotic process
regulation of mitotic cell cycle - Gene Ontology Biological Process:
- activation of JUN kinase activity
activation of MAPK activity
cellular response to mechanical stimulus
positive regulation of transcription, DNA-templated
protein phosphorylation
regulation of apoptotic process
regulation of mitotic cell cycle - Gene Ontology Molecular Function:
- ATP binding
MAP kinase kinase kinase activity
metal ion binding
protein kinase activity
protein kinase binding
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm - Keywords:
- 3D-structure
ATP-binding
Complete proteome
Cytoplasm
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Ubl conjugation - Interacts With:
- P31947; Q9UNE7