Names & Taxonomy

Uniprot ID:
Q9Y2U5
Entry Name:
M3K2_HUMAN
Status:
reviewed
Protein Names:
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Gene Names:
MAP3K2 MAPKKK2 MEKK2
Gene Names Primary:
MAP3K2
Organism:
Homo sapiens (Human)

Structure

Length:
619
Sequence:
MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme Regulation:
ENZYME REGULATION: Activated by phosphorylation on Thr-524.
Active Site:
ACT_SITE 483 483 Proton acceptor.
Cross Reference Drug Bank:
DB06616
Gene Ontology Go:
cytoplasm
cytosol
nucleoplasm
ATP binding
MAP kinase kinase kinase activity
metal ion binding
protein kinase activity
protein kinase binding
protein serine/threonine kinase activity
activation of JUN kinase activity
activation of MAPK activity
cellular response to mechanical stimulus
positive regulation of transcription, DNA-templated
protein phosphorylation
regulation of apoptotic process
regulation of mitotic cell cycle
Gene Ontology Biological Process:
activation of JUN kinase activity
activation of MAPK activity
cellular response to mechanical stimulus
positive regulation of transcription, DNA-templated
protein phosphorylation
regulation of apoptotic process
regulation of mitotic cell cycle
Gene Ontology Molecular Function:
ATP binding
MAP kinase kinase kinase activity
metal ion binding
protein kinase activity
protein kinase binding
protein serine/threonine kinase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
nucleoplasm
Keywords:
3D-structure
ATP-binding
Complete proteome
Cytoplasm
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Ubl conjugation
Interacts With:
P31947; Q9UNE7

Publication

PubMed ID:
15815621 15489334 14702039 10713157 15075238 16001074 17081983 18761086 18220336 18088087 18691976 17906693 18669648 19369195 19690332 20068231 21406692 24275569 17344846