Names & Taxonomy
- Uniprot ID:
- Q9Y2Q0
- Entry Name:
- AT8A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Phospholipid-transporting ATPase IA (EC 3.6.3.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1)
- Gene Names:
- ATP8A1 ATPIA
- Gene Names Primary:
- ATP8A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1164
- Sequence:
- MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQNSQFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHGYAFSQDENGIVSQSEVIRAYDTTKQRPDEW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane
Function
- Function:
- Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.
- Catalytic Activity:
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
- Enzyme Regulation:
- ENZYME REGULATION: ATPase activity is stimulated by phosphatidylserine (PS) and minimally by phosphatidylethanolamine (PE).
- Active Site:
- ACT_SITE 409 409 4-aspartylphosphate intermediate.
- Cross Reference Drug Bank:
- DB00144
- Gene Ontology Go:
- chromaffin granule membrane
endoplasmic reticulum
extracellular exosome
Golgi apparatus
Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
plasma membrane
trans-Golgi network
ATP binding
cation-transporting ATPase activity
magnesium ion binding
phospholipid-translocating ATPase activity
cation transmembrane transport
Golgi vesicle budding
ion transmembrane transport
learning
phospholipid translocation
positive regulation of cell migration
positive regulation of phospholipid translocation
transmembrane transport - Gene Ontology Biological Process:
- cation transmembrane transport
Golgi vesicle budding
ion transmembrane transport
learning
phospholipid translocation
positive regulation of cell migration
positive regulation of phospholipid translocation
transmembrane transport - Gene Ontology Molecular Function:
- ATP binding
cation-transporting ATPase activity
magnesium ion binding
phospholipid-translocating ATPase activity - Gene Ontology Cellular Component:
- chromaffin granule membrane
endoplasmic reticulum
extracellular exosome
Golgi apparatus
Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
plasma membrane
trans-Golgi network - Keywords:
- ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
Golgi apparatus
Hydrolase
Lipid transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport