Names & Taxonomy
- Uniprot ID:
- Q9Y2J8
- Entry Name:
- PADI2_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein-arginine deiminase type-2 (EC 3.5.3.15) (PAD-H19) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II)
- Gene Names:
- PADI2 KIAA0994 PAD2 PDI2
- Gene Names Primary:
- PADI2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 665
- Sequence:
- MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISLDVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the deimination of arginine residues of proteins.
- Catalytic Activity:
- Protein L-arginine + H(2)O = protein L-citrulline + NH(3).
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Cross Reference Drug Bank:
- DB00155
- Gene Ontology Go:
- cytoplasm
extracellular exosome
transcriptionally active chromatin
calcium ion binding
estrogen receptor binding
protein-arginine deiminase activity
chromatin-mediated maintenance of transcription
histone H3-R26 citrullination
intracellular estrogen receptor signaling pathway
negative regulation of chemokine-mediated signaling pathway
negative regulation of lymphocyte chemotaxis
protein citrullination
regulation of chromatin disassembly
substantia nigra development - Gene Ontology Biological Process:
- chromatin-mediated maintenance of transcription
histone H3-R26 citrullination
intracellular estrogen receptor signaling pathway
negative regulation of chemokine-mediated signaling pathway
negative regulation of lymphocyte chemotaxis
protein citrullination
regulation of chromatin disassembly
substantia nigra development - Gene Ontology Molecular Function:
- calcium ion binding
estrogen receptor binding
protein-arginine deiminase activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
transcriptionally active chromatin - Keywords:
- 3D-structure
Alternative splicing
Calcium
Complete proteome
Cytoplasm
Hydrolase
Reference proteome