Names & Taxonomy
- Uniprot ID:
- Q9Y289
- Entry Name:
- SC5A6_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6)
- Gene Names:
- SLC5A6 SMVT
- Gene Names Primary:
- SLC5A6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 635
- Sequence:
- MSVGVSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMFAYYQEYPMSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTVATVTTLMPLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSCQKRLHCRSYGQDHLDTGLFPEKPRNGVLGDSRDKEAMALDGTAYQGSSSTCILQETSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Transports pantothenate, biotin and lipoate in the presence of sodium.
- Cross Reference Drug Bank:
- DB00121 DB08872 DB00166
- Gene Ontology Go:
- brush border membrane
integral component of plasma membrane
membrane
plasma membrane
vesicle membrane
sodium-dependent multivitamin transmembrane transporter activity
biotin metabolic process
biotin transport
pantothenate metabolic process
pantothenate transmembrane transport
small molecule metabolic process
transmembrane transport
transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- biotin metabolic process
biotin transport
pantothenate metabolic process
pantothenate transmembrane transport
small molecule metabolic process
transmembrane transport
transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- sodium-dependent multivitamin transmembrane transporter activity
- Gene Ontology Cellular Component:
- brush border membrane
integral component of plasma membrane
membrane
plasma membrane
vesicle membrane - Keywords:
- Biotin
Complete proteome
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport