Names & Taxonomy
- Uniprot ID:
- Q9Y259
- Entry Name:
- CHKB_HUMAN
- Status:
- reviewed
- Protein Names:
- Choline/ethanolamine kinase (Choline kinase beta) (CK) (CKB) (EC 2.7.1.32) (Choline kinase-like protein) (Ethanolamine kinase) (EK) (EC 2.7.1.82) (Ethanolamine kinase beta) (EKB) (choline/ethanolamine kinase beta) (CKEKB)
- Gene Names:
- CHKB CHETK CHKL
- Gene Names Primary:
- CHKB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 395
- Sequence:
- MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLGGAWRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQGVDSLVLESVMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMPFTKEPHWLFGTMERYLKQIQDLPPTGLPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCHNDIQEGNILLLSEPENADSLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARPTDYPTQEQQLHFIRHYLAEAKKGETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS
- Proteomes:
- UP000005640
Function
- Function:
- Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.
- Pathway:
- Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
- Catalytic Activity:
- ATP + choline = ADP + phosphocholine.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.57 mM for choline
- Cross Reference Drug Bank:
- DB00122
- Gene Ontology Go:
- cytosol
ATP binding
choline kinase activity
ethanolamine kinase activity
CDP-choline pathway
glycerophospholipid biosynthetic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- CDP-choline pathway
glycerophospholipid biosynthetic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
choline kinase activity
ethanolamine kinase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Kinase
Lipid biosynthesis
Lipid metabolism
Nucleotide-binding
Phospholipid biosynthesis
Phospholipid metabolism
Reference proteome
Transferase