Names & Taxonomy
- Uniprot ID:
- Q9Y257
- Entry Name:
- KCNK6_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence)
- Gene Names:
- KCNK6 TOSS TWIK2
- Gene Names Primary:
- KCNK6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 313
- Sequence:
- MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALDAFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQLSASSHTDYASIPR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
- Intramembrane:
- INTRAMEM 90 115 Pore-forming; Name=Pore-forming 1.
Function
- Function:
- Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.
- Cross Reference Drug Bank:
- DB00308 DB00908
- Gene Ontology Go:
- plasma membrane
voltage-gated potassium channel complex
inward rectifier potassium channel activity
potassium ion leak channel activity
cardiac conduction
negative regulation of systemic arterial blood pressure
potassium ion transport
regulation of resting membrane potential
stabilization of membrane potential
synaptic transmission - Gene Ontology Biological Process:
- cardiac conduction
negative regulation of systemic arterial blood pressure
potassium ion transport
regulation of resting membrane potential
stabilization of membrane potential
synaptic transmission - Gene Ontology Molecular Function:
- inward rectifier potassium channel activity
potassium ion leak channel activity - Gene Ontology Cellular Component:
- plasma membrane
voltage-gated potassium channel complex - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel