Names & Taxonomy
- Uniprot ID:
- Q9Y234
- Entry Name:
- LIPT_HUMAN
- Status:
- reviewed
- Protein Names:
- Lipoyltransferase 1, mitochondrial (EC 2.3.1.-) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase)
- Gene Names:
- LIPT1
- Gene Names Primary:
- LIPT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 373
- Sequence:
- MLIPFSMKNCFQLLCNCQVPAAGFKKTVKNGLILQSISNDVYQNLAVEDWIHDHMNLEGKPILFFWQNSPSVVIGRHQNPWQECNLNLMREEGIKLARRRSGGGTVYHDMGNINLTFFTTKKKYDRMENLKLIVRALNAVQPQLDVQATKRFDLLLDGQFKISGTASKIGRTTAYHHCTLLCSTDGTFLSSLLKSPYQGIRSNATASIPSLVKNLLEKDPTLTCEVLMNAVATEYAAYHQIDNHIHLINPTDETLFPGINSKAKELQTWEWIYGKTPKFSINTSFHVLYEQSHLEIKVFIDIKNGRIEICNIEAPDHWLPLEIRDKLNSSLIGSKFCPTETTMLTNILLRTCPQDHKLNSKWNILCEKIKGIM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
- Pathway:
- Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.
- Catalytic Activity:
- Lipoyl-AMP + protein = protein N(6)-(lipoyl)lysine + AMP.
- Cross Reference Drug Bank:
- DB00166
- Gene Ontology Go:
- mitochondrial matrix
transferase activity, transferring acyl groups
cellular nitrogen compound metabolic process
cellular protein modification process
glyoxylate metabolic process
lipid metabolic process
protein lipoylation
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cellular protein modification process
glyoxylate metabolic process
lipid metabolic process
protein lipoylation
small molecule metabolic process - Gene Ontology Molecular Function:
- transferase activity, transferring acyl groups
- Gene Ontology Cellular Component:
- mitochondrial matrix
- Keywords:
- Acyltransferase
Complete proteome
Disease mutation
Mitochondrion
Reference proteome
Transferase
Transit peptide