Names & Taxonomy
- Uniprot ID:
- Q9Y233
- Entry Name:
- PDE10_HUMAN
- Status:
- reviewed
- Protein Names:
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) (EC 3.1.4.35)
- Gene Names:
- PDE10A
- Gene Names Primary:
- PDE10A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 779
- Sequence:
- MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Note=Located mostly to soluble cellular fractions.
Function
- Function:
- Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
- Pathway:
- Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.; Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.
- Catalytic Activity:
- Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.; Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=56 nM for cAMP
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by dipyridamole and moderately by IBMX. cAMP acts as an allosteric activator.
- Active Site:
- ACT_SITE 515 515 Proton donor.
- Cross Reference Drug Bank:
- DB00201 DB00975 DB01113 DB08811 DB08814
- Gene Ontology Go:
- cytosol
membrane
perikaryon
3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
cAMP binding
cGMP binding
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
drug binding
metal ion binding
blood coagulation
cAMP catabolic process
cGMP catabolic process
regulation of cAMP-mediated signaling
regulation of protein kinase A signaling
signal transduction - Gene Ontology Biological Process:
- blood coagulation
cAMP catabolic process
cGMP catabolic process
regulation of cAMP-mediated signaling
regulation of protein kinase A signaling
signal transduction - Gene Ontology Molecular Function:
- 3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
cAMP binding
cGMP binding
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
drug binding
metal ion binding - Gene Ontology Cellular Component:
- cytosol
membrane
perikaryon - Keywords:
- 3D-structure
Allosteric enzyme
Alternative splicing
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
cAMP
cAMP-binding
cGMP
cGMP-binding