Names & Taxonomy

Uniprot ID:
Q9UQM7
Entry Name:
KCC2A_HUMAN
Status:
reviewed
Protein Names:
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene Names:
CAMK2A CAMKA KIAA0968
Gene Names Primary:
CAMK2A
Organism:
Homo sapiens (Human)

Structure

Length:
478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, presynaptic cell membrane

Function

Function:
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation:
ENZYME REGULATION: Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.
Active Site:
ACT_SITE 135 135 Proton acceptor.
Gene Ontology Go:
cell junction
cytosol
endocytic vesicle membrane
mitochondrion
neuronal postsynaptic density
nucleoplasm
nucleus
plasma membrane
presynaptic membrane
ATP binding
calmodulin binding
calmodulin-dependent protein kinase activity
glutamate receptor binding
kinase activity
protein homodimerization activity
protein serine/threonine kinase activity
activation of MAPKK activity
angiotensin-activated signaling pathway
axon guidance
calcium ion transport
cellular response to heat
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G1/S transition of mitotic cell cycle
innate immune response
insulin receptor signaling pathway
interferon-gamma-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
peptidyl-serine phosphorylation
positive regulation of calcium ion transport
positive regulation of cardiac muscle cell apoptotic process
positive regulation of NF-kappaB transcription factor activity
protein autophosphorylation
protein phosphorylation
Ras protein signal transduction
regulation of cellular response to heat
regulation of mitochondrial membrane permeability involved in apoptotic process
regulation of neuronal synaptic plasticity
regulation of neurotransmitter secretion
response to ischemia
small GTPase mediated signal transduction
synaptic transmission
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
activation of MAPKK activity
angiotensin-activated signaling pathway
axon guidance
calcium ion transport
cellular response to heat
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G1/S transition of mitotic cell cycle
innate immune response
insulin receptor signaling pathway
interferon-gamma-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
peptidyl-serine phosphorylation
positive regulation of calcium ion transport
positive regulation of cardiac muscle cell apoptotic process
positive regulation of NF-kappaB transcription factor activity
protein autophosphorylation
protein phosphorylation
Ras protein signal transduction
regulation of cellular response to heat
regulation of mitochondrial membrane permeability involved in apoptotic process
regulation of neuronal synaptic plasticity
regulation of neurotransmitter secretion
response to ischemia
small GTPase mediated signal transduction
synaptic transmission
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
ATP binding
calmodulin binding
calmodulin-dependent protein kinase activity
glutamate receptor binding
kinase activity
protein homodimerization activity
protein serine/threonine kinase activity
Gene Ontology Cellular Component:
cell junction
cytosol
endocytic vesicle membrane
mitochondrion
neuronal postsynaptic density
nucleoplasm
nucleus
plasma membrane
presynaptic membrane
Keywords:
3D-structure
ATP-binding
Alternative splicing
Calmodulin-binding
Cell junction
Cell membrane
Complete proteome
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Synapse
Transferase
Interacts With:
Q13224

Publication

PubMed ID:
10231032 15372022 15312654