Names & Taxonomy
- Uniprot ID:
- Q9UQC9
- Entry Name:
- CLCA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium-activated chloride channel regulator 2 (EC 3.4.-.-) (Calcium-activated chloride channel family member 2) (hCLCA2) (Calcium-activated chloride channel protein 3) (CaCC-3) (hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2, 109 kDa form; Calcium-activated chloride channel regulator 2, 35 kDa form]
- Gene Names:
- CLCA2 CACC3
- Gene Names Primary:
- CLCA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 943
- Sequence:
- MTQRSIAGPICNLKFVTLLVALSSELPFLGAGVQLQDNGYNGLLIAINPQVPENQNLISNIKEMITEASFYLFNATKRRVFFRNIKILIPATWKANNNSKIKQESYEKANVIVTDWYGAHGDDPYTLQYRGCGKEGKYIHFTPNFLLNDNLTAGYGSRGRVFVHEWAHLRWGVFDEYNNDKPFYINGQNQIKVTRCSSDITGIFVCEKGPCPQENCIISKLFKEGCTFIYNSTQNATASIMFMQSLSSVVEFCNASTHNQEAPNLQNQMCSLRSAWDVITDSADFHHSFPMNGTELPPPPTFSLVQAGDKVVCLVLDVSSKMAEADRLLQLQQAAEFYLMQIVEIHTFVGIASFDSKGEIRAQLHQINSNDDRKLLVSYLPTTVSAKTDISICSGLKKGFEVVEKLNGKAYGSVMILVTSGDDKLLGNCLPTVLSSGSTIHSIALGSSAAPNLEELSRLTGGLKFFVPDISNSNSMIDAFSRISSGTGDIFQQHIQLESTGENVKPHHQLKNTVTVDNTVGNDTMFLVTWQASGPPEIILFDPDGRKYYTNNFITNLTFRTASLWIPGTAKPGHWTYTLNNTHHSLQALKVTVTSRASNSAVPPATVEAFVERDSLHFPHPVMIYANVKQGFYPILNATVTATVEPETGDPVTLRLLDDGAGADVIKNDGIYSRYFFSFAANGRYSLKVHVNHSPSISTPAHSIPGSHAMYVPGYTANGNIQMNAPRKSVGRNEEERKWGFSRVSSGGSFSVLGVPAGPHPDVFPPCKIIDLEAVKVEEELTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFSPQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDYLILKGVLTAMGLIGIICLIIVVTHHTLSRKKRADKKENGTKLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.; Calcium-activated chloride channel regulator 2, 109 kDa form: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.
Function
- Function:
- Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
- Gene Ontology Go:
- basal plasma membrane
cell junction
extracellular region
integral component of plasma membrane
nucleus
plasma membrane
chloride channel activity
intracellular calcium activated chloride channel activity
ligand-gated ion channel activity
metal ion binding
metallopeptidase activity
cell adhesion
ion transmembrane transport
transmembrane transport
transport - Gene Ontology Biological Process:
- cell adhesion
ion transmembrane transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- chloride channel activity
intracellular calcium activated chloride channel activity
ligand-gated ion channel activity
metal ion binding
metallopeptidase activity - Gene Ontology Cellular Component:
- basal plasma membrane
cell junction
extracellular region
integral component of plasma membrane
nucleus
plasma membrane - Keywords:
- Autocatalytic cleavage
Calcium
Cell adhesion
Cell junction
Cell membrane
Chloride
Complete proteome
Glycoprotein
Hydrolase
Ion transport
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix
Transport
Zinc