Names & Taxonomy
- Uniprot ID:
- Q9UPR0
- Entry Name:
- PLCL2_HUMAN
- Status:
- reviewed
- Protein Names:
- Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2)
- Gene Names:
- PLCL2 KIAA1092 PLCE2
- Gene Names Primary:
- PLCL2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1127
- Sequence:
- MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells.
Function
- Function:
- May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.
- Gene Ontology Go:
- cytoplasm
GABA receptor binding
phosphatidylinositol phospholipase C activity
signal transducer activity
B cell proliferation involved in immune response
B-1a B cell differentiation
gamma-aminobutyric acid signaling pathway
intracellular signal transduction
lipid metabolic process
negative regulation of B cell receptor signaling pathway
positive regulation of receptor binding
regulation of peptidyl-serine phosphorylation
regulation of synaptic transmission, GABAergic - Gene Ontology Biological Process:
- B-1a B cell differentiation
B cell proliferation involved in immune response
gamma-aminobutyric acid signaling pathway
intracellular signal transduction
lipid metabolic process
negative regulation of B cell receptor signaling pathway
positive regulation of receptor binding
regulation of peptidyl-serine phosphorylation
regulation of synaptic transmission, GABAergic - Gene Ontology Molecular Function:
- GABA receptor binding
phosphatidylinositol phospholipase C activity
signal transducer activity - Gene Ontology Cellular Component:
- cytoplasm
- Keywords:
- Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Phosphoprotein
Polymorphism
Reference proteome
Transducer