Names & Taxonomy
- Uniprot ID:
- Q9UPQ8
- Entry Name:
- DOLK_HUMAN
- Status:
- reviewed
- Protein Names:
- Dolichol kinase (EC 2.7.1.108) (Transmembrane protein 15)
- Gene Names:
- DOLK KIAA1094 TMEM15 UNQ2422/PRO4980
- Gene Names Orf:
- UNQ2422/PRO4980
- Gene Names Primary:
- DOLK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 538
- Sequence:
- MTRECPSPAPGPGAPLSGSVLAEAAVVFAVVLSIHATVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPFFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTLVESQGDPVDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLSLGVVLPWLHRLIRRNPLLWLLQFLFQTDTRIYLLAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.
- Catalytic Activity:
- CTP + dolichol = CDP + dolichyl phosphate.
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
dolichol kinase activity
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
dolichyl diphosphate biosynthetic process
dolichyl monophosphate biosynthetic process
post-translational protein modification
protein N-linked glycosylation via asparagine - Gene Ontology Biological Process:
- cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
dolichyl diphosphate biosynthetic process
dolichyl monophosphate biosynthetic process
post-translational protein modification
protein N-linked glycosylation via asparagine - Gene Ontology Molecular Function:
- dolichol kinase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane - Keywords:
- Complete proteome
Congenital disorder of glycosylation
Disease mutation
Endoplasmic reticulum
Kinase
Membrane
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix - Interacts With:
- Q92838