Names & Taxonomy

Uniprot ID:
Q9UPQ8
Entry Name:
DOLK_HUMAN
Status:
reviewed
Protein Names:
Dolichol kinase (EC 2.7.1.108) (Transmembrane protein 15)
Gene Names:
DOLK KIAA1094 TMEM15 UNQ2422/PRO4980
Gene Names Orf:
UNQ2422/PRO4980
Gene Names Primary:
DOLK
Organism:
Homo sapiens (Human)

Structure

Length:
538
Sequence:
MTRECPSPAPGPGAPLSGSVLAEAAVVFAVVLSIHATVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPFFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTLVESQGDPVDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLSLGVVLPWLHRLIRRNPLLWLLQFLFQTDTRIYLLAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.
Catalytic Activity:
CTP + dolichol = CDP + dolichyl phosphate.
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
dolichol kinase activity
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
dolichyl diphosphate biosynthetic process
dolichyl monophosphate biosynthetic process
post-translational protein modification
protein N-linked glycosylation via asparagine
Gene Ontology Biological Process:
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
dolichyl diphosphate biosynthetic process
dolichyl monophosphate biosynthetic process
post-translational protein modification
protein N-linked glycosylation via asparagine
Gene Ontology Molecular Function:
dolichol kinase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
Keywords:
Complete proteome
Congenital disorder of glycosylation
Disease mutation
Endoplasmic reticulum
Kinase
Membrane
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix
Interacts With:
Q92838

Publication

PubMed ID:
12213788 10470851 12975309 15164053 15489334 16923818 17273964