Names & Taxonomy
- Uniprot ID:
- Q9UP52
- Entry Name:
- TFR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Transferrin receptor protein 2 (TfR2)
- Gene Names:
- TFR2
- Gene Names Primary:
- TFR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 801
- Sequence:
- MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSRPRQPNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSEDVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNHSGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTKEDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFYFLSQYVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type II membrane protein.; Isoform Beta: Cytoplasm
Function
- Function:
- Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
- Cross Reference Drug Bank:
- DB05260
- Gene Ontology Go:
- cytoplasmic vesicle
external side of plasma membrane
HFE-transferrin receptor complex
integral component of plasma membrane
co-receptor binding
glycoprotein binding
transferrin receptor activity
cellular iron ion homeostasis
cellular response to iron ion
ferrous iron import into cell
iron ion homeostasis
iron ion transport
positive regulation of endocytosis
positive regulation of peptide hormone secretion
positive regulation of protein maturation
positive regulation of transcription from RNA polymerase II promoter
receptor-mediated endocytosis
response to iron ion
transferrin transport - Gene Ontology Biological Process:
- cellular iron ion homeostasis
cellular response to iron ion
ferrous iron import into cell
iron ion homeostasis
iron ion transport
positive regulation of endocytosis
positive regulation of peptide hormone secretion
positive regulation of protein maturation
positive regulation of transcription from RNA polymerase II promoter
receptor-mediated endocytosis
response to iron ion
transferrin transport - Gene Ontology Molecular Function:
- co-receptor binding
glycoprotein binding
transferrin receptor activity - Gene Ontology Cellular Component:
- cytoplasmic vesicle
external side of plasma membrane
HFE-transferrin receptor complex
integral component of plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix