Names & Taxonomy

Uniprot ID:
Q9UNQ0
Entry Name:
ABCG2_HUMAN
Status:
reviewed
Protein Names:
ATP-binding cassette sub-family G member 2 (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338)
Gene Names:
ABCG2 ABCP BCRP BCRP1 MXR
Gene Names Primary:
ABCG2
Organism:
Homo sapiens (Human)

Structure

Length:
655
Sequence:
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
Cross Reference Drug Bank:
DB08916 DB11363 DB06605 DB00921 DB06772 DB00958 DB00515 DB00242 DB00631 DB09065 DB05239 DB00286 DB00091 DB08912 DB09102 DB00970 DB01254 DB00694 DB01234 DB00255 DB01248 DB00997 DB00470 DB00530 DB00783 DB00655 DB00773 DB00973 DB00544 DB00158 DB00317 DB01016 DB01094 DB00741 DB09054 DB00619 DB00762 DB00602 DB00709 DB00448 DB01097 DB09078 DB00563 DB01204 DB00688 DB00220 DB04868 DB00698 DB01051 DB00338 DB09330 DB00526 DB01229 DB00213 DB06589 DB08860 DB08901 DB00175 DB00457 DB01129 DB08896 DB08864 DB00740 DB00503 DB09291 DB01098 DB01232 DB08934 DB00398 DB00795 DB00669 DB01268 DB00675 DB00966 DB00444 DB08880 DB00624 DB01030 DB05294 DB08881 DB00285 DB00661 DB00541 DB08828 DB00549 DB00495
Gene Ontology Go:
apical plasma membrane
integral component of membrane
mitochondrial membrane
nucleus
plasma membrane
ATP binding
ATPase activity, coupled to transmembrane movement of substances
heme transporter activity
protein homodimerization activity
transporter activity
xenobiotic-transporting ATPase activity
cellular iron ion homeostasis
cellular response to dexamethasone stimulus
drug export
drug transmembrane transport
embryonic process involved in female pregnancy
heme transport
response to drug
response to folic acid
response to iron ion
small molecule metabolic process
transmembrane transport
transport
urate metabolic process
xenobiotic transport
Gene Ontology Biological Process:
cellular iron ion homeostasis
cellular response to dexamethasone stimulus
drug export
drug transmembrane transport
embryonic process involved in female pregnancy
heme transport
response to drug
response to folic acid
response to iron ion
small molecule metabolic process
transmembrane transport
transport
urate metabolic process
xenobiotic transport
Gene Ontology Molecular Function:
ATPase activity, coupled to transmembrane movement of substances
ATP binding
heme transporter activity
protein homodimerization activity
transporter activity
xenobiotic-transporting ATPase activity
Gene Ontology Cellular Component:
apical plasma membrane
integral component of membrane
mitochondrial membrane
nucleus
plasma membrane
Keywords:
ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Membrane
Mitochondrion
Nucleotide-binding
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:
P11309-1; P0CG48

Publication

PubMed ID:
9850061 9861027 11306452 11533706 12958161 14702039 15815621 15489334 9892175 11590207 15001581 15807535 15670731 15769853 17686774 18834626 19506252 20368174 20705604 22132962 22509477 22246507 22246505 23189181 12111378 15618737 12544509 15838659 16702730