Names & Taxonomy
- Uniprot ID:
- Q9UNI1
- Entry Name:
- CELA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase-1) (Pancreatic elastase 1)
- Gene Names:
- CELA1 ELA1
- Gene Names Primary:
- CELA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 258
- Sequence:
- MLVLYGHSTQDLPETNARVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGGTLIRQNWVMTAAHCVDYQKTFRVVAGDHNLSQNDGTEQYVSVQKIVVHPYWNSDNVAAGYDIALLRLAQSVTLNSYVQLGVLPQEGAILANNSPCYITGWGKTKTNGQLAQTLQQAYLPSVDYAICSSSSYWGSTVKNTMVCAGGDGVRSGCQGDSGGPLHCLVNGKYSVHGVTSFVSSRGCNVSRKPTVFTQVSAYISWINNVIASN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Acts upon elastin.
- Catalytic Activity:
- Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 63 63 Charge relay system.
- Gene Ontology Go:
- extracellular space
metal ion binding
serine-type endopeptidase activity
elastin catabolic process
exocrine pancreas development
inflammatory response
multicellular organism growth
negative regulation of transcription from RNA polymerase II promoter
pancreas morphogenesis
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
post-embryonic development
regulation of cell differentiation
regulation of cell proliferation
tissue remodeling
Wnt signaling pathway - Gene Ontology Biological Process:
- elastin catabolic process
exocrine pancreas development
inflammatory response
multicellular organism growth
negative regulation of transcription from RNA polymerase II promoter
pancreas morphogenesis
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
post-embryonic development
regulation of cell differentiation
regulation of cell proliferation
tissue remodeling
Wnt signaling pathway - Gene Ontology Molecular Function:
- metal ion binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- extracellular space
- Keywords:
- Calcium
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Zymogen